Intracellular lipid binding proteins of the small intestine

The small intestine contains three distinct proteins belonging to the intracellular lipid binding protein family: the liver-type fatty acid binding protein (L-FABP), the intestinal fatty acid binding protein (I-FABP) and the ileal lipid binding protein (ilbp). The function of these proteins in the s...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and cellular biochemistry 2002-10, Vol.239 (1-2), p.79-82
Main Authors: Agellon, Luis B, Toth, Matthew J, Thomson, Alan B R
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - genetics
Carrier Proteins - metabolism
Dietary Fats - metabolism
Fatty Acid-Binding Protein 7
Fatty Acid-Binding Proteins
Fatty acids
Intestinal Absorption - physiology
Intestine, Small - metabolism
Lipids
Mice
Mice, Knockout
Neoplasm Proteins
Nerve Tissue Proteins
Proteins
Small intestine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The small intestine contains three distinct proteins belonging to the intracellular lipid binding protein family: the liver-type fatty acid binding protein (L-FABP), the intestinal fatty acid binding protein (I-FABP) and the ileal lipid binding protein (ilbp). The function of these proteins in the small intestine has remained enigmatic. Targeted gene disruption studies may shed insights into the physiological importance of these proteins. In the case of I-FABP, this approach has demonstrated that the complete elimination of this protein in murine intestine does not compromise dietary fat absorption in vivo but is associated with the development of insulin resistance.
ISSN:0300-8177
1573-4919
DOI:10.1023/A:1020520521025