Scanning laser polarimetric analysis of retinal nerve fiber layer thickness in Turkish patients with glaucoma and ocular hypertension

To assess the thickness of the retinal nerve fiber layer (RNFL) in patients with different stages of glaucoma, in comparison with ocular hypertensive (OHT) and healthy subjects in a Turkish population. Scanning laser polarimetry was done with a GDx Nerve Fiber Analyzer (NFA, GDx version, 1.0.08) on...

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Bibliographic Details
Published in:European journal of ophthalmology 2002-09, Vol.12 (5), p.406-412
Main Authors: BOZKURT, B, IRKEC, M, KARAAGAOGLU, E, ORHAN, M
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Diagnostic Techniques, Ophthalmological
Female
Glaucoma - pathology
Glaucoma and intraocular pressure
Humans
Lasers
Male
Medical sciences
Middle Aged
Nerve Fibers - pathology
Ocular Hypertension - pathology
Ophthalmology
Reference Values
Retina - pathology
Sensitivity and Specificity
Tropical medicine
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Summary:To assess the thickness of the retinal nerve fiber layer (RNFL) in patients with different stages of glaucoma, in comparison with ocular hypertensive (OHT) and healthy subjects in a Turkish population. Scanning laser polarimetry was done with a GDx Nerve Fiber Analyzer (NFA, GDx version, 1.0.08) on 270 eyes with glaucoma, 52 OHT eyes, and 81 normal eyes. The eyes were classified as having early (146 eyes), moderate (66 eyes) and severe (58 eyes) glaucoma based on the Humphrey Visual Field indices. We compared 14 NFA parameters by analysis of variance (ANOVA) and Scheffe multiple comparison analysis. Receiver operator characteristic curves (ROC) and Fisher linear discriminant analysis (LDF) were used to measure the sensitivity and specificity of the NFA parameters. Except for symmetry, all NFA parameters showed significant differences between the groups (p
ISSN:1120-6721
1724-6016
DOI:10.1177/112067210201200511