Post-oxidative conversion of thiol residue to sulfonic acid in the binding sites of molecularly imprinted polymers: Disulfide based covalent molecular imprinting for basic compounds

An imprinted polymer using a disulfide derivative as a template was treated with NaBH4 to yield the polymer with thiol groups in the binding sites. The thiol groups were then oxidized with H2O2/AcOH to yield the molecularly imprinted polymer with sulfo groups in the binding sites. This site conversi...

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Bibliographic Details
Published in:Analyst (London) 2002-11, Vol.127 (11), p.1407-1409
Main Authors: MUKAWA, Takashi, GOTO, Takeshi, TAKEUCHI, Toshifumi
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Exact sciences and technology
General, instrumentation
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Summary:An imprinted polymer using a disulfide derivative as a template was treated with NaBH4 to yield the polymer with thiol groups in the binding sites. The thiol groups were then oxidized with H2O2/AcOH to yield the molecularly imprinted polymer with sulfo groups in the binding sites. This site conversion can provide amine-imprinted polymers, in which amine is retained to the imprinted polymer by the strong electrostatic interaction between the amino group and the sulfo group in the binding sites.
ISSN:0003-2654
1364-5528
DOI:10.1039/b206831a