Pharmacokinetic studies of ambenonium chloride in patients with myasthenia gravis

Serum levels of ambenonium chloride (AC) were monitored in 4 myasthenic patients. This determination revealed important intraindividual variations (up to 10-fold) over a period of 24 h. Levels varied considerably between different patients (maximum serum concentration of ambenonium chloride ranged f...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 1991-10, Vol.16 (4), p.299-303
Main Authors: THARASSE-BLOCH, C, CHABENAT, C, BOUCLY, P, MARCHAND, J, ELKHARRAT, D, BOUCLY-GOESTER, C, GAJDOS, P
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Aged
Aged, 80 and over
Ambenonium Chloride - blood
Ambenonium Chloride - pharmacokinetics
Biological and medical sciences
Biological Availability
Female
Humans
Male
Medical sciences
Muscle
Myasthenia Gravis - metabolism
Pharmacology. Drug treatments
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Summary:Serum levels of ambenonium chloride (AC) were monitored in 4 myasthenic patients. This determination revealed important intraindividual variations (up to 10-fold) over a period of 24 h. Levels varied considerably between different patients (maximum serum concentration of ambenonium chloride ranged from 0.129 to 0.812 micrograms/ml) and no correlation between the daily dose and the AUC was found. These characteristic properties of ambenonium chloride could explain the erratic pattern of bioavailability observed as well as the difficulty in controlling the disease in some patients.
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03189975