Estimation of impurity profiles of drugs and related materials. Part VIII: Combined application of high- performance liquid chromatography and NMR spectroscopy in the impurity profiling of drugs

The usefulness of the joint application of HPLC and NMR spectroscopy in drug impurity profiling is demonstrated by the following examples: (1) identification of Z and E isomers of 17α-ethynyl-4-oestrene-3β,17-diol-3- acetate-17-(3′-acetoxy-2′-butenoate) in ethynodiol diacetate; (2) identification of...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1991, Vol.9 (10), p.829-833
Main Authors: Görög, S., Balogh, G., Gazdag, M.
Format: Article
Language:English
Subjects:
Analysis
Androstane-3,17-diol - analogs & derivatives
Androstane-3,17-diol - analysis
Biological and medical sciences
Chromatography, High Pressure Liquid
drug impurity profiling
Enalapril - analogs & derivatives
Enalapril - analysis
enalapril maleate
ethynodiol diacetate
Ethynodiol Diacetate - analogs & derivatives
Ethynodiol Diacetate - analysis
General pharmacology
HPLC
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Neuromuscular Blocking Agents - analysis
NMR spectroscopy
Pharmacology. Drug treatments
Pipecuronium
pipecuronium bromide
Piperazines - analysis
Stereoisomerism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The usefulness of the joint application of HPLC and NMR spectroscopy in drug impurity profiling is demonstrated by the following examples: (1) identification of Z and E isomers of 17α-ethynyl-4-oestrene-3β,17-diol-3- acetate-17-(3′-acetoxy-2′-butenoate) in ethynodiol diacetate; (2) identification of the p-tolyl analogue as the impurity of enalapril maleate; (3) identification and quantification of 2′-dehydro-pipecuronium bromide in pipecuronium bromide. The possibilities of utilizing NMR spectroscopy for the identification and quantification of the impurities with and without their isolation are discussed.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(91)80009-X