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A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy
To compare the prophylactic antiemetic efficacy of the combination of ondansetron and droperidol with that of droperidol alone in patients undergoing elective laparoscopic cholecystectomy. Randomized, double-blind controlled trial. University affiliated teaching hospital after induction of standardi...
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| Published in: | Journal of clinical anesthesia 2002-11, Vol.14 (7), p.481-485 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c391t-5bd165b2f7ac3502e88ca456dc6b6c87b6e4a47107e29d7b513a6f37d008f97c3 |
| container_end_page | 485 |
| container_issue | 7 |
| container_start_page | 481 |
| container_title | Journal of clinical anesthesia |
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| creator | Awad, Imad T Murphy, Deirde Stack, Damian Swanton, Brian J Meeke, Rodney I Shorten, George D |
| description | To compare the prophylactic antiemetic efficacy of the combination of ondansetron and droperidol with that of droperidol alone in patients undergoing elective laparoscopic cholecystectomy.
Randomized, double-blind controlled trial.
University affiliated teaching hospital after induction of standardized general anesthesia.
64 ASA physical status I or II patients aged 18 to 80 years, undergoing elective laparoscopic cholecystectomy.
Following induction of general anesthesia, patients received either droperidol 1.25 mg intravenously (IV; n = 30; Group D) or the combination of droperidol 1.25 mg IV and ondansetron 4 mg IV (n = 34; Group D+O).
Number and severity of nausea episodes, number of emetic episodes, total analgesic consumption, and rescue antiemetic administration were assessed at 1, 3, and 24 hours after admission to the recovery room. Data were analyzed using Fisher’s Exact test and unpaired Student’s
t-test; a
p-value |
| doi_str_mv | 10.1016/S0952-8180(02)00394-X |
| format | article |
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Randomized, double-blind controlled trial.
University affiliated teaching hospital after induction of standardized general anesthesia.
64 ASA physical status I or II patients aged 18 to 80 years, undergoing elective laparoscopic cholecystectomy.
Following induction of general anesthesia, patients received either droperidol 1.25 mg intravenously (IV; n = 30; Group D) or the combination of droperidol 1.25 mg IV and ondansetron 4 mg IV (n = 34; Group D+O).
Number and severity of nausea episodes, number of emetic episodes, total analgesic consumption, and rescue antiemetic administration were assessed at 1, 3, and 24 hours after admission to the recovery room. Data were analyzed using Fisher’s Exact test and unpaired Student’s
t-test; a
p-value <0.05 was considered significant.
The proportions of patients who experienced nausea (70% and 53% for D and D+O groups, respectively) and vomiting (30% and 19% for D and D+O groups, respectively) were similar in the two groups. The frequency of moderate and severe nausea (requiring administration of antiemetic) was less in group D + O (7%) compared with group D (19%;
p < 0.05).
Patients who received the combination of droperidol and ondansetron experienced less severe nausea compared with patients who received droperidol alone.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/S0952-8180(02)00394-X</identifier><identifier>PMID: 12477581</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anesthesia, General ; Antiemetics - therapeutic use ; Biological and medical sciences ; Cholecystectomy ; Cholecystectomy, Laparoscopic - adverse effects ; Digestive system ; Double-Blind Method ; droperidol ; Droperidol - therapeutic use ; Drug Therapy, Combination ; Elective Surgical Procedures ; Female ; Humans ; laparoscopic ; Male ; Medical sciences ; Middle Aged ; nausea and vomiting ; ondansetron ; Ondansetron - therapeutic use ; Pharmacology. Drug treatments ; postoperative ; Postoperative Nausea and Vomiting - drug therapy</subject><ispartof>Journal of clinical anesthesia, 2002-11, Vol.14 (7), p.481-485</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 by Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-5bd165b2f7ac3502e88ca456dc6b6c87b6e4a47107e29d7b513a6f37d008f97c3</citedby><cites>FETCH-LOGICAL-c391t-5bd165b2f7ac3502e88ca456dc6b6c87b6e4a47107e29d7b513a6f37d008f97c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14430889$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12477581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awad, Imad T</creatorcontrib><creatorcontrib>Murphy, Deirde</creatorcontrib><creatorcontrib>Stack, Damian</creatorcontrib><creatorcontrib>Swanton, Brian J</creatorcontrib><creatorcontrib>Meeke, Rodney I</creatorcontrib><creatorcontrib>Shorten, George D</creatorcontrib><title>A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>To compare the prophylactic antiemetic efficacy of the combination of ondansetron and droperidol with that of droperidol alone in patients undergoing elective laparoscopic cholecystectomy.
Randomized, double-blind controlled trial.
University affiliated teaching hospital after induction of standardized general anesthesia.
64 ASA physical status I or II patients aged 18 to 80 years, undergoing elective laparoscopic cholecystectomy.
Following induction of general anesthesia, patients received either droperidol 1.25 mg intravenously (IV; n = 30; Group D) or the combination of droperidol 1.25 mg IV and ondansetron 4 mg IV (n = 34; Group D+O).
Number and severity of nausea episodes, number of emetic episodes, total analgesic consumption, and rescue antiemetic administration were assessed at 1, 3, and 24 hours after admission to the recovery room. Data were analyzed using Fisher’s Exact test and unpaired Student’s
t-test; a
p-value <0.05 was considered significant.
The proportions of patients who experienced nausea (70% and 53% for D and D+O groups, respectively) and vomiting (30% and 19% for D and D+O groups, respectively) were similar in the two groups. The frequency of moderate and severe nausea (requiring administration of antiemetic) was less in group D + O (7%) compared with group D (19%;
p < 0.05).
Patients who received the combination of droperidol and ondansetron experienced less severe nausea compared with patients who received droperidol alone.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia, General</subject><subject>Antiemetics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cholecystectomy</subject><subject>Cholecystectomy, Laparoscopic - adverse effects</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>droperidol</subject><subject>Droperidol - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Elective Surgical Procedures</subject><subject>Female</subject><subject>Humans</subject><subject>laparoscopic</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nausea and vomiting</subject><subject>ondansetron</subject><subject>Ondansetron - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>postoperative</subject><subject>Postoperative Nausea and Vomiting - drug therapy</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rHSEYhaU0NDdpf0KLm5Z0Mak6HzqrEkK_IJBFWshOHH1NLDM6VefC_WH9f3XuvTTQTVei53l9D-cg9JqSS0po9-GO9C2rBBXkgrD3hNR9U90_QxsqeF01Leufo81f5BSdpfSTEFIE-gKdUtZw3gq6Qb-vsA7TrKJLweNgcX4EDNaCzmm9mhhmiM6EEStv9mrhB-dVdoeBf4jgjfIJclxVj-eQ8qoXfAvYqyWB2nPbMLns_AO2IeK5yODLxsUbiA9hfR9VcRWSDrPTWD-GEfQu5eIrTLuX6MSqMcGr43mOfnz-9P36a3Vz--Xb9dVNpeue5qodDO3agVmudN0SBkJo1bSd0d3QacGHDhrVcEo4sN7woaW16mzNDSHC9lzX5-jd4d85hl8LpCwnlzSMo_IQliQ54x2jHS1gewB1sZwiWDlHN6m4k5TItS-570uuZUjC5L4veV_m3hwXLMME5mnqWFAB3h4BlbQabVReu_TENU1NhOgL9_HAQYlj6yDKpEukGoyLJTNpgvuPlT97trgL</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Awad, Imad T</creator><creator>Murphy, Deirde</creator><creator>Stack, Damian</creator><creator>Swanton, Brian J</creator><creator>Meeke, Rodney I</creator><creator>Shorten, George D</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy</title><author>Awad, Imad T ; Murphy, Deirde ; Stack, Damian ; Swanton, Brian J ; Meeke, Rodney I ; Shorten, George D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-5bd165b2f7ac3502e88ca456dc6b6c87b6e4a47107e29d7b513a6f37d008f97c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia, General</topic><topic>Antiemetics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cholecystectomy</topic><topic>Cholecystectomy, Laparoscopic - adverse effects</topic><topic>Digestive system</topic><topic>Double-Blind Method</topic><topic>droperidol</topic><topic>Droperidol - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Elective Surgical Procedures</topic><topic>Female</topic><topic>Humans</topic><topic>laparoscopic</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nausea and vomiting</topic><topic>ondansetron</topic><topic>Ondansetron - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>postoperative</topic><topic>Postoperative Nausea and Vomiting - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awad, Imad T</creatorcontrib><creatorcontrib>Murphy, Deirde</creatorcontrib><creatorcontrib>Stack, Damian</creatorcontrib><creatorcontrib>Swanton, Brian J</creatorcontrib><creatorcontrib>Meeke, Rodney I</creatorcontrib><creatorcontrib>Shorten, George D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awad, Imad T</au><au>Murphy, Deirde</au><au>Stack, Damian</au><au>Swanton, Brian J</au><au>Meeke, Rodney I</au><au>Shorten, George D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>14</volume><issue>7</issue><spage>481</spage><epage>485</epage><pages>481-485</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>To compare the prophylactic antiemetic efficacy of the combination of ondansetron and droperidol with that of droperidol alone in patients undergoing elective laparoscopic cholecystectomy.
Randomized, double-blind controlled trial.
University affiliated teaching hospital after induction of standardized general anesthesia.
64 ASA physical status I or II patients aged 18 to 80 years, undergoing elective laparoscopic cholecystectomy.
Following induction of general anesthesia, patients received either droperidol 1.25 mg intravenously (IV; n = 30; Group D) or the combination of droperidol 1.25 mg IV and ondansetron 4 mg IV (n = 34; Group D+O).
Number and severity of nausea episodes, number of emetic episodes, total analgesic consumption, and rescue antiemetic administration were assessed at 1, 3, and 24 hours after admission to the recovery room. Data were analyzed using Fisher’s Exact test and unpaired Student’s
t-test; a
p-value <0.05 was considered significant.
The proportions of patients who experienced nausea (70% and 53% for D and D+O groups, respectively) and vomiting (30% and 19% for D and D+O groups, respectively) were similar in the two groups. The frequency of moderate and severe nausea (requiring administration of antiemetic) was less in group D + O (7%) compared with group D (19%;
p < 0.05).
Patients who received the combination of droperidol and ondansetron experienced less severe nausea compared with patients who received droperidol alone.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12477581</pmid><doi>10.1016/S0952-8180(02)00394-X</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of clinical anesthesia, 2002-11, Vol.14 (7), p.481-485 |
| issn | 0952-8180 1873-4529 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Anesthesia, General Antiemetics - therapeutic use Biological and medical sciences Cholecystectomy Cholecystectomy, Laparoscopic - adverse effects Digestive system Double-Blind Method droperidol Droperidol - therapeutic use Drug Therapy, Combination Elective Surgical Procedures Female Humans laparoscopic Male Medical sciences Middle Aged nausea and vomiting ondansetron Ondansetron - therapeutic use Pharmacology. Drug treatments postoperative Postoperative Nausea and Vomiting - drug therapy |
| title | A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy |
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