Curcumin Induces Caspase-3-Independent Apoptosis in Human Multidrug-Resistant Cells

: Curcumin, the major component of the spice turmeric, used in 50‐μM concentration, induced cell death in multidrug‐resistant CEMP‐gp4 and LoVoP‐gp4 cells as well as in their sensitive counterparts as assessed by TUNEL method and morphological observation. In all cells induced to undergo cell death...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-11, Vol.973 (1), p.250-254
Main Authors: PIWOCKA, KATARZYNA, BIELAK-MIJEWSKA, ANNA, SIKORA, EWA
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Caspase 3
Caspases - metabolism
cell death
curcumin
Curcumin - pharmacology
Drug Resistance, Multiple - physiology
Humans
MDR cells
Tumor Cells, Cultured
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Summary:: Curcumin, the major component of the spice turmeric, used in 50‐μM concentration, induced cell death in multidrug‐resistant CEMP‐gp4 and LoVoP‐gp4 cells as well as in their sensitive counterparts as assessed by TUNEL method and morphological observation. In all cells induced to undergo cell death with curcumin, there was no caspase‐3 activation because only the unprocessed form of caspase‐3 was observed using immunoblotting.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04643.x