Extracellular ATP Induces Phosphatidylserine Externalization Earlier than Nuclear Apoptotic Events in Thymocytes

: The present study shows for the first time that ATPec induces a very early PS exposure in thymocytes and that this process can be induced in the absence of Ca2+ influx and caspase activation.

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-11, Vol.973 (1), p.186-189
Main Authors: COURAGEOT, MARIE-PIERRE, LEPINE, SANDRINE, GIRAUD, FRANCOISE, SULPICE, JEAN-CLAUDE
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - pharmacology
Animals
apoptosis
Apoptosis - physiology
Ca2
Calcium - pharmacology
Cell Nucleus - physiology
Cell Nucleus - ultrastructure
Cells, Cultured
extracellular ATP (ATPec)
Extracellular Space - physiology
Mice
phosphatidylserine (PS)
Phosphatidylserines - metabolism
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
T-Lymphocytes - physiology
thymocytes
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Description
Summary:: The present study shows for the first time that ATPec induces a very early PS exposure in thymocytes and that this process can be induced in the absence of Ca2+ influx and caspase activation.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04630.x