The comparative pathogenesis of neosporosis

Since its first description in dogs in 1984, the protozoan parasite Neospora caninum has been found to infect a wide range of animals, worldwide. In cattle, N. caninum has particular significance as a cause of abortion in which persistence of infection in the mother, recrudescence of the parasite du...

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Bibliographic Details
Published in:Trends in Parasitology 2002-12, Vol.18 (12), p.546-552
Main Authors: Buxton, David, McAllister, Milton M, Dubey, J.P
Format: Article
Language:English
Subjects:
Animal productions
Animal protozoal diseases
Animals
Biological and medical sciences
bovine animals
Cattle
Coccidiosis - parasitology
Coccidiosis - pathology
Coccidiosis - veterinary
Dogs
Female
Fundamental and applied biological sciences. Psychology
Goats
Horses
Host-Parasite Interactions
Humans
Infectious diseases
Life Cycle Stages
Medical sciences
Models, Animal
Models, Biological
Neospora - pathogenicity
Neospora caninum
Parasitic diseases
pathogenesis
Protozoal diseases
Sheep
Swine
Terrestrial animal productions
Vertebrates
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Summary:Since its first description in dogs in 1984, the protozoan parasite Neospora caninum has been found to infect a wide range of animals, worldwide. In cattle, N. caninum has particular significance as a cause of abortion in which persistence of infection in the mother, recrudescence of the parasite during pregnancy, and the vulnerability of the placenta and foetus to invasion are important features. This article discusses how Neospora invades cells, how it infects and causes disease in several animal species, and particularly how it has evolved a special niche in cattle and dogs that ensures its survival. The protozoan Neospora caninum infects many animal species, but in dogs and cattle, it can cause significant disease when it exploits the altered immune status of pregnancy to transmit itself to the next generation
ISSN:1471-4922
1471-5007
DOI:10.1016/S1471-4922(02)02414-5