Gout due to renal disease

From 120 patients attending a referral gout clinic, 12 patients were found to have primary renal disease at the time of, or prior to, their first attack of acute gouty arthritis. This number excluded those with chronic lead nephropathy, polycystic kidneys or who were receiving diuretics. The nature...

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Bibliographic Details
Published in:British journal of rheumatology 1992, Vol.31 (1), p.63-65
Main Authors: VECCHIO, P. C, EMMERSON, B. T
Format: Article
Language:English
Subjects:
Adult
Arthritis, Gouty - etiology
Biological and medical sciences
Cysts - complications
Female
Gout - etiology
Gout - genetics
Humans
Kidney Diseases - complications
Kidney Diseases - genetics
Male
Medical sciences
Metabolic diseases
Other metabolic disorders
Purines and pyrimidines (gout, hyperuricemia...)
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Summary:From 120 patients attending a referral gout clinic, 12 patients were found to have primary renal disease at the time of, or prior to, their first attack of acute gouty arthritis. This number excluded those with chronic lead nephropathy, polycystic kidneys or who were receiving diuretics. The nature of the renal disease was usually of the tubulointerstitial variety rather than of glomerular origin. The renal clearance of urate per unit of glomerular filtration rate, which usually increases with renal disease, was generally reduced, suggesting impairment of renal excretion of urate. Nine of the patients were female (four premenopausal) and only three were males. The degree of renal impairment was only mild to moderate. Other common associations with gout, such as obesity, hypertension and regular alcohol consumption, were not prominent. The intrinsic renal disease in these patients was considered to be the major contributor to their development of hyperuricaemia and gout.
ISSN:0263-7103
1460-2172