The significance of mannan-binding lectin gene alleles in patients with primary Sjögren's syndrome

To investigate the significance or mannan-binding lectin (MBL) gene alleles in patients with primary Sjogren's syndrome (pSS). Genotypes were determined in 65 pSS patients and 138 controls. No difference in MBL genotype or allele frequencies was detected between the pSS patients and controls. H...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology 2002, Vol.31 (6), p.362-365
Main Authors: AITTONIEMI, J, PERTOVAARA, M, HULKKONEN, J, PASTERNACK, A, HURME, M, LAIPPALA, P, ANTONEN, J
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
Female
Genetic Predisposition to Disease
Genotype
Humans
Inflammation
Male
Mannose-Binding Lectin - genetics
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Polymorphism, Genetic
Salivary Glands - pathology
Sjogren's Syndrome - genetics
Sjogren's Syndrome - pathology
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:To investigate the significance or mannan-binding lectin (MBL) gene alleles in patients with primary Sjogren's syndrome (pSS). Genotypes were determined in 65 pSS patients and 138 controls. No difference in MBL genotype or allele frequencies was detected between the pSS patients and controls. However, when the effect of MBL genotypes on the diagnostic findings in pSS patients was assessed, none of the eight patients with 52/w genotype fulfilled four (definite) Californian criteria (P = 0.007). Among these eight the Chisholm-Mason histological grade was > or = 3 in only three (P = 0.017). Furthermore, the MBL concentration was lower in patients with 52/w genotype compared to those with wild-type (w/w) genotype (P = 0.035). Our findings suggest that MBL structural gene polymorphisms do not influence on susceptibility to pSS. However, MBL may be associated with salivary gland destruction in pSS, and its concentration may be comparable with the intensity of inflammatory reaction. Further studies are warranted to clarify the possible mechanisms involved.
ISSN:0300-9742
1502-7732
DOI:10.1080/030097402320817095