First two patients with ulcerative colitis who developed classical thrombotic thrombocytopenic purpura successfully treated with medical therapy and plasma exchange

The association of ulcerative colitis (UC) and thrombotic thrombocytopenic purpura (TTP) is rare. Only one prior patient with these two syndromes has been reported in the literature. In that case, splenectomy and proctectomy were performed to control the symptoms of TTP. We present two patients with...

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Bibliographic Details
Published in:Journal of clinical apheresis 2002, Vol.17 (4), p.204-206
Main Authors: Baron, Beverly W., Jeon, Hye-Ran, Glunz, Catherine, Peterson, Amy, Cohen, Russell, Hanauer, Stephen, Rubin, David, Hart, John, Baron, Joseph M.
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Autoimmune Diseases - complications
Autoimmune Diseases - therapy
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Colitis, Ulcerative - complications
Colitis, Ulcerative - therapy
Female
Hematologic and hematopoietic diseases
Humans
Medical sciences
Middle Aged
plasma exchange
Plasma Exchange - methods
Platelet diseases and coagulopathies
Prednisone - therapeutic use
Purpura, Thrombotic Thrombocytopenic - etiology
Purpura, Thrombotic Thrombocytopenic - therapy
thrombotic thrombocytopenic purpura
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Treatment Outcome
ulcerative colitis
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Summary:The association of ulcerative colitis (UC) and thrombotic thrombocytopenic purpura (TTP) is rare. Only one prior patient with these two syndromes has been reported in the literature. In that case, splenectomy and proctectomy were performed to control the symptoms of TTP. We present two patients with UC who developed TTP and were successfully treated with multiple plasma exchanges (PEXs) in conjunction with medical therapy without the necessity for surgical intervention. Acquired TTP may be another extraintestinal autoimmune feature of UC. TTP in association with UC may be refractory to high‐dose steroids and PEX, possibly requiring vincristine and splenectomy, as in the one previously reported case, to achieve remission. J. Clin. Apheresis 17:204–206, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:0733-2459
1098-1101
DOI:10.1002/jca.10037