Further Immunohistochemical Evidence for Impaired NO Signaling in the Hypothalamus of Depressed Patients

: The cellular expression of nitric oxide synthase (NOS) was studied in neurons of the Nuc. suprachiasmaticus (SCN) of depressed patients and matched controls. The number of NOS‐immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied b...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-11, Vol.973 (1), p.91-93
Main Authors: BERNSTEIN, H.-G., HEINEMANN, A., KRELL, D., MAWRIN, C., BIELAU, H., DANOS, P., DIEKMANN, S., KEILHOFF, G., BOGERTS, B., BAUMANN, B.
Format: Article
Language:English
Subjects:
depression
Depressive Disorder - genetics
Depressive Disorder - pathology
Depressive Disorder - physiopathology
Gene Expression Regulation, Enzymologic
Humans
Hypothalamus - enzymology
Hypothalamus - pathology
Immunohistochemistry
neurophysin
Nitric Oxide - physiology
nitric oxide synthase
Nitric Oxide Synthase - analysis
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase Type I
Reference Values
Signal Transduction - physiology
suprachiasmatic nucleus
Suprachiasmatic Nucleus - enzymology
Suprachiasmatic Nucleus - pathology
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Summary:: The cellular expression of nitric oxide synthase (NOS) was studied in neurons of the Nuc. suprachiasmaticus (SCN) of depressed patients and matched controls. The number of NOS‐immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied by impaired hypothalamic NO signaling.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04613.x