Pharmacokinetic Consequences of Spaceflight

Spaceflight induces a wide range of physiological and biochemical changes, including disruption of gastrointestinal (GI) function, fluid and electrolyte balance, circulatory dynamics, and organ blood flow, as well as hormonal and metabolic perturbations. Any of these changes can influence the pharma...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1991-02, Vol.618 (1), p.615-618
Main Authors: PUTCHA, LAKSHMI, CINTRÓN, NITZA M.
Format: Article
Language:English
Subjects:
Acetaminophen - blood
Acetaminophen - pharmacokinetics
Acetaminophen - urine
Aerospace Medicine
Bed Rest
Biological Availability
Dextroamphetamine - blood
Dextroamphetamine - pharmacokinetics
Dextroamphetamine - urine
Humans
Saliva - metabolism
Scopolamine - blood
Scopolamine - pharmacokinetics
Scopolamine - urine
Space Flight
Space life sciences
Time Factors
Weightlessness
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Summary:Spaceflight induces a wide range of physiological and biochemical changes, including disruption of gastrointestinal (GI) function, fluid and electrolyte balance, circulatory dynamics, and organ blood flow, as well as hormonal and metabolic perturbations. Any of these changes can influence the pharmacokinetics and pharmacodynamics of in-flight medication. That spaceflight may alter bioavailability was proposed when drugs prescribed to alleviate space motion sickness (SMS) had little therapeutic effect. Characterization of the pharmacokinetic and/or pharmacodynamic behavior of operationally critical medications is crucial for their effective use in flight; as a first step, we sought to determine whether drugs administered in space actually reach the site of action at concentrations sufficient to elicit the therapeutic response.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1991.tb27292.x