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Effect of Andrographolide and Kan Jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture
The immunomodulatory properties of a diterpene lactone andrographolide and Kan Jang – a standardized fixed combination of Andrographis paniculata extract SHA-10 and Eleutherococcus senticosus extract SHE-3 were investigated. Their role on spontaneous and phytohemagglutinin (PHA)-induced proliferatio...
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| Published in: | Phytomedicine (Stuttgart) 2002-10, Vol.9 (7), p.598-605 |
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| creator | Panossian, A. Davtyan, T. Gukassyan, N. Gukasova, G. Mamikonyan, G. Gabrielian, E. Wikman, G. |
| description | The immunomodulatory properties of a diterpene lactone andrographolide and Kan Jang – a standardized fixed combination of
Andrographis paniculata extract SHA-10 and
Eleutherococcus senticosus extract SHE-3 were investigated. Their role on spontaneous and phytohemagglutinin (PHA)-induced proliferation of human peripheral blood lymphocytes (PBL) and on production of interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α) were determined
in vitro. Proliferation of PBL induced by PHA was enhanced by co stimulation with andrographolide and Kan Jang. At the same time andrographolide and Kan Jang inhibit spontaneous proliferation of PBL
in vitro. These preparations also have effect on the formation of INF-γ, TNF-α and some immune activation markers such as neopterin (Neo), β-2-microglobulin (β2MG), and soluble receptor for interleukin-2 (sIL-2R or sCD25) in blood cells culture. Andrographolide and Kan Jang stimulate the INF-γ, Neopterin and β2MG formation, but do not have any significant effect on the production of INF-γ and Neopterin in PHA stimulated blood cells. An opposite effect on these immune makers was observed in the PHA-stimulated blood cells: both andrographolide and Kan Jang increase the formation of TNF-α and β2MG in cultivated whole blood cells.
Thus, andrographolide and Kan Jang can have an
in vitro effect on the activation and proliferation of immunocompetent cells as well on the production of key cytokines and immune activation markers. The results show an overall higher effect of the fixed combination as compared with the equivalent amount of the pure substance andrographolide. The data are consistent with results from clinical studies of Kan Jang and contributed to a better understanding of these results. |
| doi_str_mv | 10.1078/094471102321616409 |
| format | article |
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Andrographis paniculata extract SHA-10 and
Eleutherococcus senticosus extract SHE-3 were investigated. Their role on spontaneous and phytohemagglutinin (PHA)-induced proliferation of human peripheral blood lymphocytes (PBL) and on production of interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α) were determined
in vitro. Proliferation of PBL induced by PHA was enhanced by co stimulation with andrographolide and Kan Jang. At the same time andrographolide and Kan Jang inhibit spontaneous proliferation of PBL
in vitro. These preparations also have effect on the formation of INF-γ, TNF-α and some immune activation markers such as neopterin (Neo), β-2-microglobulin (β2MG), and soluble receptor for interleukin-2 (sIL-2R or sCD25) in blood cells culture. Andrographolide and Kan Jang stimulate the INF-γ, Neopterin and β2MG formation, but do not have any significant effect on the production of INF-γ and Neopterin in PHA stimulated blood cells. An opposite effect on these immune makers was observed in the PHA-stimulated blood cells: both andrographolide and Kan Jang increase the formation of TNF-α and β2MG in cultivated whole blood cells.
Thus, andrographolide and Kan Jang can have an
in vitro effect on the activation and proliferation of immunocompetent cells as well on the production of key cytokines and immune activation markers. The results show an overall higher effect of the fixed combination as compared with the equivalent amount of the pure substance andrographolide. The data are consistent with results from clinical studies of Kan Jang and contributed to a better understanding of these results.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1078/094471102321616409</identifier><identifier>PMID: 12487323</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Andrographis ; Andrographis paniculata ; andrographolide ; Biomarkers ; Blood Cells - cytology ; Blood Cells - drug effects ; Blood Cells - metabolism ; Cells, Cultured ; Cytokines - biosynthesis ; Diterpenes - pharmacology ; Eleutherococcus ; Eleutherococcus senticosus ; Glucosides - pharmacology ; Humans ; INF-γ ; Interferon-gamma - biosynthesis ; Interferon-gamma - drug effects ; Kan Jang ; Lignans ; lymphocytes ; Lymphocytes - cytology ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; neopterin ; Plant Extracts - pharmacology ; SHA-10 ; sIL-2R ; TNF-α ; Tumor Necrosis Factor-alpha - biosynthesis ; β-2-microglobulin</subject><ispartof>Phytomedicine (Stuttgart), 2002-10, Vol.9 (7), p.598-605</ispartof><rights>2002 Urban & Fischer Verlag</rights><rights>COPYRIGHT 2002 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag Oct 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-22c4edec18ecc11045e70a9658adb236341519f6c514552ee4da6e856f84c2df3</citedby><cites>FETCH-LOGICAL-c454t-22c4edec18ecc11045e70a9658adb236341519f6c514552ee4da6e856f84c2df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12487323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panossian, A.</creatorcontrib><creatorcontrib>Davtyan, T.</creatorcontrib><creatorcontrib>Gukassyan, N.</creatorcontrib><creatorcontrib>Gukasova, G.</creatorcontrib><creatorcontrib>Mamikonyan, G.</creatorcontrib><creatorcontrib>Gabrielian, E.</creatorcontrib><creatorcontrib>Wikman, G.</creatorcontrib><title>Effect of Andrographolide and Kan Jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>The immunomodulatory properties of a diterpene lactone andrographolide and Kan Jang – a standardized fixed combination of
Andrographis paniculata extract SHA-10 and
Eleutherococcus senticosus extract SHE-3 were investigated. Their role on spontaneous and phytohemagglutinin (PHA)-induced proliferation of human peripheral blood lymphocytes (PBL) and on production of interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α) were determined
in vitro. Proliferation of PBL induced by PHA was enhanced by co stimulation with andrographolide and Kan Jang. At the same time andrographolide and Kan Jang inhibit spontaneous proliferation of PBL
in vitro. These preparations also have effect on the formation of INF-γ, TNF-α and some immune activation markers such as neopterin (Neo), β-2-microglobulin (β2MG), and soluble receptor for interleukin-2 (sIL-2R or sCD25) in blood cells culture. Andrographolide and Kan Jang stimulate the INF-γ, Neopterin and β2MG formation, but do not have any significant effect on the production of INF-γ and Neopterin in PHA stimulated blood cells. An opposite effect on these immune makers was observed in the PHA-stimulated blood cells: both andrographolide and Kan Jang increase the formation of TNF-α and β2MG in cultivated whole blood cells.
Thus, andrographolide and Kan Jang can have an
in vitro effect on the activation and proliferation of immunocompetent cells as well on the production of key cytokines and immune activation markers. The results show an overall higher effect of the fixed combination as compared with the equivalent amount of the pure substance andrographolide. The data are consistent with results from clinical studies of Kan Jang and contributed to a better understanding of these results.</description><subject>Andrographis</subject><subject>Andrographis paniculata</subject><subject>andrographolide</subject><subject>Biomarkers</subject><subject>Blood Cells - cytology</subject><subject>Blood Cells - drug effects</subject><subject>Blood Cells - metabolism</subject><subject>Cells, Cultured</subject><subject>Cytokines - biosynthesis</subject><subject>Diterpenes - pharmacology</subject><subject>Eleutherococcus</subject><subject>Eleutherococcus senticosus</subject><subject>Glucosides - pharmacology</subject><subject>Humans</subject><subject>INF-γ</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - drug effects</subject><subject>Kan Jang</subject><subject>Lignans</subject><subject>lymphocytes</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - metabolism</subject><subject>neopterin</subject><subject>Plant Extracts - pharmacology</subject><subject>SHA-10</subject><subject>sIL-2R</subject><subject>TNF-α</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>β-2-microglobulin</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp9ksFu1DAURSMEokPhB1ggiwWrBmzHcRKJzagaKFCJBSCxizz284zbxB7spHR2_AN_2C_hZWagElQoC0fP597cXL0se8roS0ar-hVthKgYo7zgTDIpaHMvm-FbndOm_Ho_m01AjkRxlD1K6YJSJpqKPsyOGBd1VfBilt0srAU9kGDJ3JsYVlFt1qFzBojyhnxQnrxXfkVufvwk1l2DITr0S-fV4IKfVHA9RIUGn87mOaM70e1okRc7JaKbiK4W4h_heuzRvNv2-D29HSCdTIwZ9W8Ah-HSeUg7U9f3o8dQeH219-hVvISYiPNkWAP5jrGBLLsQMCN0XSJ67IYxwuPsgVVdgieH8zj78mbx-fQsP__49t3p_DzXohRDzrkWYECzGrTGVkUJFVWNLGtllryQhWAla6zUJRNlyQGEURLqUtpaaG5scZy92Pvib3wbIQ1t79KURHkIY2orXlVNXXEEn_8FXoQxeszWclqWRS0LitDJHlqpDlrnbZhKXYHHCrvgwToczxvJZSV5hXh-B46Pgd7pu3i-53UMKUWw7SY6bHTbMtpO29X-u10oenYIPi57MLeSwzoh8HoPAPZ85SC2STvwGoyLuGWtCe5__r8A4xDg-w</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Panossian, A.</creator><creator>Davtyan, T.</creator><creator>Gukassyan, N.</creator><creator>Gukasova, G.</creator><creator>Mamikonyan, G.</creator><creator>Gabrielian, E.</creator><creator>Wikman, G.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Effect of Andrographolide and Kan Jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture</title><author>Panossian, A. ; Davtyan, T. ; Gukassyan, N. ; Gukasova, G. ; Mamikonyan, G. ; Gabrielian, E. ; Wikman, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-22c4edec18ecc11045e70a9658adb236341519f6c514552ee4da6e856f84c2df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Andrographis</topic><topic>Andrographis paniculata</topic><topic>andrographolide</topic><topic>Biomarkers</topic><topic>Blood Cells - cytology</topic><topic>Blood Cells - drug effects</topic><topic>Blood Cells - metabolism</topic><topic>Cells, Cultured</topic><topic>Cytokines - biosynthesis</topic><topic>Diterpenes - pharmacology</topic><topic>Eleutherococcus</topic><topic>Eleutherococcus senticosus</topic><topic>Glucosides - pharmacology</topic><topic>Humans</topic><topic>INF-γ</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - drug effects</topic><topic>Kan Jang</topic><topic>Lignans</topic><topic>lymphocytes</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - metabolism</topic><topic>neopterin</topic><topic>Plant Extracts - pharmacology</topic><topic>SHA-10</topic><topic>sIL-2R</topic><topic>TNF-α</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>β-2-microglobulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panossian, A.</creatorcontrib><creatorcontrib>Davtyan, T.</creatorcontrib><creatorcontrib>Gukassyan, N.</creatorcontrib><creatorcontrib>Gukasova, G.</creatorcontrib><creatorcontrib>Mamikonyan, G.</creatorcontrib><creatorcontrib>Gabrielian, E.</creatorcontrib><creatorcontrib>Wikman, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panossian, A.</au><au>Davtyan, T.</au><au>Gukassyan, N.</au><au>Gukasova, G.</au><au>Mamikonyan, G.</au><au>Gabrielian, E.</au><au>Wikman, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Andrographolide and Kan Jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>9</volume><issue>7</issue><spage>598</spage><epage>605</epage><pages>598-605</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>The immunomodulatory properties of a diterpene lactone andrographolide and Kan Jang – a standardized fixed combination of
Andrographis paniculata extract SHA-10 and
Eleutherococcus senticosus extract SHE-3 were investigated. Their role on spontaneous and phytohemagglutinin (PHA)-induced proliferation of human peripheral blood lymphocytes (PBL) and on production of interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α) were determined
in vitro. Proliferation of PBL induced by PHA was enhanced by co stimulation with andrographolide and Kan Jang. At the same time andrographolide and Kan Jang inhibit spontaneous proliferation of PBL
in vitro. These preparations also have effect on the formation of INF-γ, TNF-α and some immune activation markers such as neopterin (Neo), β-2-microglobulin (β2MG), and soluble receptor for interleukin-2 (sIL-2R or sCD25) in blood cells culture. Andrographolide and Kan Jang stimulate the INF-γ, Neopterin and β2MG formation, but do not have any significant effect on the production of INF-γ and Neopterin in PHA stimulated blood cells. An opposite effect on these immune makers was observed in the PHA-stimulated blood cells: both andrographolide and Kan Jang increase the formation of TNF-α and β2MG in cultivated whole blood cells.
Thus, andrographolide and Kan Jang can have an
in vitro effect on the activation and proliferation of immunocompetent cells as well on the production of key cytokines and immune activation markers. The results show an overall higher effect of the fixed combination as compared with the equivalent amount of the pure substance andrographolide. The data are consistent with results from clinical studies of Kan Jang and contributed to a better understanding of these results.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>12487323</pmid><doi>10.1078/094471102321616409</doi><tpages>8</tpages></addata></record> |
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| ispartof | Phytomedicine (Stuttgart), 2002-10, Vol.9 (7), p.598-605 |
| issn | 0944-7113 1618-095X |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Andrographis Andrographis paniculata andrographolide Biomarkers Blood Cells - cytology Blood Cells - drug effects Blood Cells - metabolism Cells, Cultured Cytokines - biosynthesis Diterpenes - pharmacology Eleutherococcus Eleutherococcus senticosus Glucosides - pharmacology Humans INF-γ Interferon-gamma - biosynthesis Interferon-gamma - drug effects Kan Jang Lignans lymphocytes Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism neopterin Plant Extracts - pharmacology SHA-10 sIL-2R TNF-α Tumor Necrosis Factor-alpha - biosynthesis β-2-microglobulin |
| title | Effect of Andrographolide and Kan Jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture |
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