A Dinuclear Zn Catalyst for the Asymmetric Nitroaldol (Henry) Reaction

A high level of enantioselectivity (78–93 % ee) and high yields (58–90 %) are obtained in the enantioselective nitroaldol reaction of nitromethane with several aldehydes when a novel dinuclear zinc catalyst is employed (see scheme).

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2002-03, Vol.41 (5), p.861-863
Main Authors: Trost, Barry M., Yeh, Vince S. C.
Format: Article
Language:English
Subjects:
Alcohols - chemistry
Aldehydes - chemistry
asymmetric catalysis
Catalysis
chiral ligands
Methane - analogs & derivatives
Methane - chemistry
nitroaldol reaction
Nitroparaffins - chemistry
zinc
Zinc - chemistry
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Description
Summary:A high level of enantioselectivity (78–93 % ee) and high yields (58–90 %) are obtained in the enantioselective nitroaldol reaction of nitromethane with several aldehydes when a novel dinuclear zinc catalyst is employed (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020301)41:5<861::AID-ANIE861>3.0.CO;2-V