Concomitant occurrence of canine malposition and tooth agenesis: Evidence of orofacial genetic fields

Certain discrete malpositions of the human canine tooth and agenesis of at least 1 tooth (hypodontia) are abnormalities known to occur together frequently. This study examines the specificity of tooth-agenesis sites associated with the occurrence of 3 unambiguous canine malpositions: palatally displ...

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Bibliographic Details
Published in:American journal of orthodontics and dentofacial orthopedics 2002-12, Vol.122 (6), p.657-660
Main Authors: Peck, Sheldon, Peck, Leena, Kataja, Matti
Format: Article
Language:English
Subjects:
Adolescent
Anodontia - complications
Anodontia - genetics
Bicuspid - abnormalities
Child
Cuspid - abnormalities
Dentistry
DNA-Binding Proteins - physiology
Female
Gene Expression
Homeodomain Proteins - physiology
Humans
Incisor - abnormalities
Inheritance Patterns
Male
Molar - abnormalities
Molar, Third - abnormalities
MSX1 Transcription Factor
PAX9 Transcription Factor
Phenotype
Tooth Eruption, Ectopic - complications
Tooth Eruption, Ectopic - genetics
Transcription Factors - physiology
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Summary:Certain discrete malpositions of the human canine tooth and agenesis of at least 1 tooth (hypodontia) are abnormalities known to occur together frequently. This study examines the specificity of tooth-agenesis sites associated with the occurrence of 3 unambiguous canine malpositions: palatally displaced canine (PDC; n = 58), mandibular lateral incisor-canine transposition (Mn.I2.C; n = 60), and maxillary canine-first premolar transposition (Mx.C.P1; n = 43). A fourth sample was formed from 4 cases of combined occurrence of PDC and Mn.I2.C, the only combination-phenotype noted among the 161 subjects. Oral panoramic radiographs were used to identify agenesis of at least 1 third molar (M3), mandibular second premolar (MnP2), and maxillary lateral incisor (MxI2)—the 3 most frequently absent tooth types among people of European descent. PDC and Mn.I2.C transposition appear to be associated with significantly increased M3 agenesis (P
ISSN:0889-5406
1097-6752
DOI:10.1067/mod.2002.129915