Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity

The GALR1 galanin receptor is expressed at high levels within the central nervous system. To determine which specific actions of galanin are mediated by GALR1, we have developed mice with an insertional inactivating mutation within the gene encoding GALR1 (Galr1). Homozygous Galr1 −/− mice are viabl...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 2002-11, Vol.107 (2), p.195-200
Main Authors: Jacoby, Arie Steven, Hort, Yvonne Janet, Constantinescu, George, Shine, John, Iismaa, Tiina Pauline
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - physiology
Biological and medical sciences
Body Weight - genetics
Cell receptors
Cell structures and functions
Central Nervous System - growth & development
Central Nervous System - metabolism
Central Nervous System - physiopathology
Down-Regulation - genetics
Epilepsy
Female
Fundamental and applied biological sciences. Psychology
Galanin - metabolism
IGF-I
Insulin-Like Growth Factor I - deficiency
Knockout mouse
Lactation - genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Molecular and cellular biology
Molecular Sequence Data
Neuropeptide
Neuropeptide receptors
Neurosecretory Systems - growth & development
Neurosecretory Systems - metabolism
Neurosecretory Systems - physiopathology
Phenotype
Receptors, Galanin
Receptors, Neuropeptide - deficiency
Receptors, Neuropeptide - genetics
Seizures
Seizures - genetics
Seizures - metabolism
Seizures - physiopathology
Sex Characteristics
Sex Distribution
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Summary:The GALR1 galanin receptor is expressed at high levels within the central nervous system. To determine which specific actions of galanin are mediated by GALR1, we have developed mice with an insertional inactivating mutation within the gene encoding GALR1 (Galr1). Homozygous Galr1 −/− mice are viable and capable of breeding. They exhibit no significant difference in growth rate relative to Galr1 +/+ controls but have reduced circulating levels of insulin-like growth factor-I (IGF-I) and exhibit spontaneous tonic–clonic seizures. The phenotype of these mice identifies a critical role for GALR1 in neuroendocrine regulation and in mediating the anti-seizure activity of galanin.
ISSN:0169-328X
1872-6941
DOI:10.1016/S0169-328X(02)00451-5