Molecular Biology of the Calcium Antagonist Receptor

The calcium channel plays a key role in controlling many physiological processes in the body. Drugs that block the calcium channel have proven clinically effective for the treatment of a multitude of cardiovascular disorders. The elucidation of the precise mechanism of action of these drugs involves...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-01, Vol.19 (1), p.19-24
Main Authors: Slish, Donald F, Schultz, David, Schwartz, Arnold
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological and medical sciences
Calcium Channel Blockers - metabolism
Calcium Channels
Cardiovascular system
Humans
Medical sciences
Miscellaneous
Molecular Biology - methods
Molecular Sequence Data
Muscle, Smooth - metabolism
Myocardium - metabolism
Pharmacology. Drug treatments
Receptors, Nicotinic - genetics
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Summary:The calcium channel plays a key role in controlling many physiological processes in the body. Drugs that block the calcium channel have proven clinically effective for the treatment of a multitude of cardiovascular disorders. The elucidation of the precise mechanism of action of these drugs involves cloning the calcium channels on which they act. Genetic manipulation of these cloned channels is beginning to reveal the binding sites for the calcium channel blocking drugs and may lead to the development of more specific agents.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.19.1.19