Interaction of ACTH, β-endorphin and α-melanocyte stimulating hormone in relation to the corticosteroid production of isolated rat adrenocortical zona fasciculata and zona glomerulosa cells

• Published in: FEBS letters 1992-01, Vol.296 (1), p.87-89
• Main Authors: Szalay, Katalin Sz, Folly, Gábor
• Format: Article
• Language: English
• Subjects: ACTH; Adrenocortical Steroidogenesis; Adrenocorticotropic Hormone - metabolism; adrenocorticotropin; Aldosterone; Aldosterone - biosynthesis; alpha -melanocyte stimulating hormone; Animals; beta -endorphin; beta-Endorphin - metabolism; Biological and medical sciences; Cell physiology; Corticosterone - biosynthesis; effects on; Fundamental and applied biological sciences. Psychology; Hormonal regulation; In Vitro Techniques; Male; Melanocyte-Stimulating Hormones - metabolism; Molecular and cellular biology; Pro-Opiomelanocortin - analogs & derivatives; Pro-Opiomelanocortin - metabolism; Proopiomelanocortin; Rats; steroidogenesis; Zona Fasciculata - metabolism; Zona Glomerulosa - metabolism; α-MSH; β-Endorphin
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(92)80409-A

The combined effects of ACTH, β-endorphin (β-EP) and α-MSH were studied on the corticosteroidogenesis or isolated rat adrenocortical zona fasciculata and zona glomerulosa cells. β-EP potentiated the effects of ACTH and α-MSH on the zona fasciculata corticosterone production but inhibited those on the zona glomerulosa aldosterone production. β-EP did not affect the combined action of 4×10 −11 M ACTH and 5×10 −9 M α-MSH on the zona fasciculata or the zona glomerulosa cells, but it inhibited the stimulatory action of the combination of 1.6×10 −10 M ACTH and 10 −9 M α-MSH on the zona glomerulosa aldosterone production. An interaction of ACTH, β-EP and α-MSH in relation to the zona fasciculata and zona glomerulosa corticosteroid production was found.