MRI predicts area of increased plasminogen activation in permanent focal cerebral ischemia

• Published in: Neurological research (New York) 2002-12, Vol.24 (8), p.822-824
• Main Authors: Pfefferkorn, Thomas, Wiessner, Christoph, Allegrini, Peter R., Kloss, Christian U.A., Hamann, Gerhard F.
• Format: Article
• Language: English
• Subjects: Animals; Brain Edema - metabolism; Brain Edema - pathology; Brain Edema - physiopathology; Brain Ischemia - metabolism; Brain Ischemia - pathology; Brain Ischemia - physiopathology; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - pathology; Cerebral Hemorrhage - physiopathology; Cerebral Infarction - metabolism; Cerebral Infarction - pathology; Cerebral Infarction - physiopathology; CEREBRAL ISCHEMIA; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; IN SITU ZYMOGRAPHY; MAGNETIC RESONANCE IMAGING; Male; Matrix Metalloproteinases - metabolism; Plasminogen - metabolism; PLASMINOGEN ACTIVATION; Plasminogen Activators - metabolism; Predictive Value of Tests; Rats; Rats, Inbred F344; Statistics as Topic; Telencephalon - metabolism; Telencephalon - pathology; Telencephalon - physiopathology; Up-Regulation - physiology
• ISSN: 0161-6412; 1743-1328
• DOI: 10.1179/016164102101200799

To determine if MRI can predict intracerebral plasminogen activation after focal cerebral ischemia (FCI), ischemic regions detected by MRI after 48 h of permanent FCI in rats were compared with areas of increased plasminogen activation, defined by histological zymography after 72 h of ischemia. The overlap between areas of MRI alterations (64.5% ± 5.4% of total ischemic hemisphere) and areas with increased plasminogen activation (62.2% ± 3.6%) was significant for the hemisphere (p < 0.001), the cortex (p < 0.05), and the basal ganglia (p < 0.05). Thus, MRI can predict the extent of increased plasminogen activation, which may play a role in BBB-mediated post-ischemic brain edema and secondary hemorrhage.