Fluorinated amino acids in protein design and engineering

Selective incorporation of unnatural amino acids into proteins is a powerful tool for illuminating the principles of protein design. In particular, fluorinated amino acids have recently emerged as valuable building blocks for designing hyperstable protein folds, as well as directing highly specific...

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Bibliographic Details
Published in:Chemical Society reviews 2002-11, Vol.31 (6), p.335-341
Main Authors: Yoder, Nicholas C, Kumar, Krishna
Format: Article
Language:English
Subjects:
Amino Acids - chemistry
Fluorine - chemistry
Fluorocarbons - chemistry
Molecular Mimicry
Protein Conformation
Protein Engineering - methods
Proteins - chemical synthesis
Proteins - chemistry
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Summary:Selective incorporation of unnatural amino acids into proteins is a powerful tool for illuminating the principles of protein design. In particular, fluorinated amino acids have recently emerged as valuable building blocks for designing hyperstable protein folds, as well as directing highly specific protein-protein interactions. We review the collagen mimetic and coiled coil peptide systems that exemplify generalizable paradigms for future design. The unique electronic and phase properties of fluorocarbons are discussed, and protein synthesis using unnatural amino acids is briefly reviewed.
ISSN:0306-0012
1460-4744
DOI:10.1039/b201097f