Extrinsic neural regulation of antroduodenal motor activity in preterm infants

This study was designed to assess whether extrinsic neural regulation of antroduodenal motor function is present in preterm neonates. Antroduodenal motor patterns were recorded in 48 infants during fasting and after a 10 ml/kg/15 min orograstric feeding. Plasma concentrations of pancreatic polypepti...

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Bibliographic Details
Published in:Digestive diseases and sciences 2002-12, Vol.47 (12), p.2657-2663
Main Authors: AL-TAWIL, Youhanna, KLEE, George, BERSETH, Carol Lynn
Format: Article
Language:English
Subjects:
Atropine - pharmacology
Biological and medical sciences
Delivery. Postpartum. Lactation
Disorders
Duodenum - physiology
Gastric Emptying - drug effects
Gastric Emptying - physiology
Gynecology. Andrology. Obstetrics
Heart Rate - drug effects
Humans
Infant, Newborn
Infant, Premature - physiology
Manometry
Medical sciences
Pancreatic Polypeptide - blood
Postprandial Period - physiology
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Summary:This study was designed to assess whether extrinsic neural regulation of antroduodenal motor function is present in preterm neonates. Antroduodenal motor patterns were recorded in 48 infants during fasting and after a 10 ml/kg/15 min orograstric feeding. Plasma concentrations of pancreatic polypeptide were determined before and after each feeding. Of 48 infants, 24 had adult like duodenal motor responses to feeding, and they released pancreatic polypeptide postprandially. When 18 of these 24 infants were given atropine, their heart rates increased. Feedings, however, now failed to trigger adultlike duodenal motor responses or postprandial release of pancreatic polypeptide. Those 24 infants who lacked adultlike responses failed to release pancreatic polypeptide postprandially. When a subset of 10 of these infants was given atropine, feedings failed to trigger adultlike motor responses or release of pancreatic polypeptide. We conclude that extrinsic neural regulation of duodenal motor patterns is present in only about half of preterm infants.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1021084517391