Dynamic combinatorial chemistry

A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic...

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Bibliographic Details
Published in:Drug Discovery Today 2002-01, Vol.7 (2), p.117-125
Main Authors: Otto, Sijbren, Furlan, Ricardo L.E, Sanders, Jeremy K.M
Format: Article
Language:English
Subjects:
Amplification
Biological and medical sciences
Combinatorial Chemistry Techniques - methods
Disulfide exchange
General pharmacology
Hydrazone exchange
Medical sciences
Molecular Conformation
Molecular recognition
Peptide Library
Peptides - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Reversible chemistry
Templating
Thermodynamic control
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Summary:A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional combinatorial chemistry, and that could make a useful addition to the set of combinatorial techniques used in drug discovery.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(01)02086-4