Nalidixic acid prodrugs: amides from amino acid ester and nalidixic acid

Amides from amino acid ester and nalidixic acid were synthesized. The solubility characteristics and partition coefficient of the compounds were studied. The hydrolysis of the compounds was studied in the simulated gastric fluid and simulated intestinal fluid. Some compounds showed better antibacter...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 1991-03, Vol.14 (1), p.48-51
Main Authors: Taori, A, Nema, R, Kohli, D V, Uppadhyay, R K
Format: Article
Language:English
Subjects:
Amides - chemical synthesis
Amides - pharmacology
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Colony Count, Microbial
Escherichia coli - drug effects
Nalidixic Acid - analogs & derivatives
Nalidixic Acid - chemical synthesis
Nalidixic Acid - pharmacology
Prodrugs - chemical synthesis
Prodrugs - pharmacology
Salmonella typhi - drug effects
Solubility
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amides from amino acid ester and nalidixic acid were synthesized. The solubility characteristics and partition coefficient of the compounds were studied. The hydrolysis of the compounds was studied in the simulated gastric fluid and simulated intestinal fluid. Some compounds showed better antibacterial activity than nalidixic acid.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02857814