The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction

LH plays critical roles in the control of folliculogenesis and ovarian function in humans. LH activity administration during gonadotrophin ovulation induction can enhance ovarian response and optimise treatment. More specifically, LH activity (both LH and low-dose hCG) can support the growth and sti...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction update 2002-11, Vol.8 (6), p.543-557
Main Authors: Filicori, Marco, Cognigni, Graciela E., Samara, Arafat, Melappioni, Silvia, Perri, Tiziana, Cantelli, Barbara, Parmegiani, Lodovico, Pelusi, Giuseppe, DeAloysio, Domenico
Format: Article
Language:English
Subjects:
Chorionic Gonadotropin - administration & dosage
Female
folliculogenesis
Humans
Hypogonadism
LH activity
luteinizing hormone
Luteinizing Hormone - administration & dosage
Luteinizing Hormone - physiology
Menotropins
Ovarian Follicle - physiology
ovarian function
Ovary - physiology
Ovulation Induction
Polycystic Ovary Syndrome
Recombinant Proteins
Reproductive Techniques, Assisted
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:LH plays critical roles in the control of folliculogenesis and ovarian function in humans. LH activity administration during gonadotrophin ovulation induction can enhance ovarian response and optimise treatment. More specifically, LH activity (both LH and low-dose hCG) can support the growth and stimulate the maturation of larger ovarian follicles as a result of specific granulosa cell receptors that develop after a few days of FSH priming. This action of LH is independent of FSH, and it has been shown recently that the last stages of follicular development can be supported by sole administration of LH activity in the form of low-dose hCG, without causing premature luteinization. Reproductively competent oocytes and pregnancy can be obtained with this regimen. Furthermore, LH activity is capable of reducing the development of small ovarian follicles (
ISSN:1355-4786
1460-2369
DOI:10.1093/humupd/8.6.543