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The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction
LH plays critical roles in the control of folliculogenesis and ovarian function in humans. LH activity administration during gonadotrophin ovulation induction can enhance ovarian response and optimise treatment. More specifically, LH activity (both LH and low-dose hCG) can support the growth and sti...
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| Published in: | Human reproduction update 2002-11, Vol.8 (6), p.543-557 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 557 |
| container_issue | 6 |
| container_start_page | 543 |
| container_title | Human reproduction update |
| container_volume | 8 |
| creator | Filicori, Marco Cognigni, Graciela E. Samara, Arafat Melappioni, Silvia Perri, Tiziana Cantelli, Barbara Parmegiani, Lodovico Pelusi, Giuseppe DeAloysio, Domenico |
| description | LH plays critical roles in the control of folliculogenesis and ovarian function in humans. LH activity administration during gonadotrophin ovulation induction can enhance ovarian response and optimise treatment. More specifically, LH activity (both LH and low-dose hCG) can support the growth and stimulate the maturation of larger ovarian follicles as a result of specific granulosa cell receptors that develop after a few days of FSH priming. This action of LH is independent of FSH, and it has been shown recently that the last stages of follicular development can be supported by sole administration of LH activity in the form of low-dose hCG, without causing premature luteinization. Reproductively competent oocytes and pregnancy can be obtained with this regimen. Furthermore, LH activity is capable of reducing the development of small ovarian follicles ( |
| doi_str_mv | 10.1093/humupd/8.6.543 |
| format | article |
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LH activity administration during gonadotrophin ovulation induction can enhance ovarian response and optimise treatment. More specifically, LH activity (both LH and low-dose hCG) can support the growth and stimulate the maturation of larger ovarian follicles as a result of specific granulosa cell receptors that develop after a few days of FSH priming. This action of LH is independent of FSH, and it has been shown recently that the last stages of follicular development can be supported by sole administration of LH activity in the form of low-dose hCG, without causing premature luteinization. Reproductively competent oocytes and pregnancy can be obtained with this regimen. Furthermore, LH activity is capable of reducing the development of small ovarian follicles (<10 mm) that may predispose patients to developing complications such as the ovarian hyperstimulation syndrome. Thus, better understanding of the dynamics and mechanisms that control human folliculogenesis and a more rational and selective use of LH activity administration may allow a reduction in cost and increased safety, while maintaining a high efficacy of the ovulation induction regimens used in assisted reproduction.</description><identifier>ISSN: 1355-4786</identifier><identifier>EISSN: 1460-2369</identifier><identifier>DOI: 10.1093/humupd/8.6.543</identifier><identifier>PMID: 12498424</identifier><identifier>CODEN: HRUPF8</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Chorionic Gonadotropin - administration & dosage ; Female ; folliculogenesis ; Humans ; Hypogonadism ; LH activity ; luteinizing hormone ; Luteinizing Hormone - administration & dosage ; Luteinizing Hormone - physiology ; Menotropins ; Ovarian Follicle - physiology ; ovarian function ; Ovary - physiology ; Ovulation Induction ; Polycystic Ovary Syndrome ; Recombinant Proteins ; Reproductive Techniques, Assisted</subject><ispartof>Human reproduction update, 2002-11, Vol.8 (6), p.543-557</ispartof><rights>Copyright Oxford University Press(England) Nov 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-1bfba914bdc8cd9498367597f1909d03939c8d844034d4838cceb97edabd9eac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12498424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Filicori, Marco</creatorcontrib><creatorcontrib>Cognigni, Graciela E.</creatorcontrib><creatorcontrib>Samara, Arafat</creatorcontrib><creatorcontrib>Melappioni, Silvia</creatorcontrib><creatorcontrib>Perri, Tiziana</creatorcontrib><creatorcontrib>Cantelli, Barbara</creatorcontrib><creatorcontrib>Parmegiani, Lodovico</creatorcontrib><creatorcontrib>Pelusi, Giuseppe</creatorcontrib><creatorcontrib>DeAloysio, Domenico</creatorcontrib><title>The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction</title><title>Human reproduction update</title><addtitle>Hum. Reprod. Update</addtitle><description>LH plays critical roles in the control of folliculogenesis and ovarian function in humans. LH activity administration during gonadotrophin ovulation induction can enhance ovarian response and optimise treatment. More specifically, LH activity (both LH and low-dose hCG) can support the growth and stimulate the maturation of larger ovarian follicles as a result of specific granulosa cell receptors that develop after a few days of FSH priming. This action of LH is independent of FSH, and it has been shown recently that the last stages of follicular development can be supported by sole administration of LH activity in the form of low-dose hCG, without causing premature luteinization. Reproductively competent oocytes and pregnancy can be obtained with this regimen. Furthermore, LH activity is capable of reducing the development of small ovarian follicles (<10 mm) that may predispose patients to developing complications such as the ovarian hyperstimulation syndrome. Thus, better understanding of the dynamics and mechanisms that control human folliculogenesis and a more rational and selective use of LH activity administration may allow a reduction in cost and increased safety, while maintaining a high efficacy of the ovulation induction regimens used in assisted reproduction.</description><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>Female</subject><subject>folliculogenesis</subject><subject>Humans</subject><subject>Hypogonadism</subject><subject>LH activity</subject><subject>luteinizing hormone</subject><subject>Luteinizing Hormone - administration & dosage</subject><subject>Luteinizing Hormone - physiology</subject><subject>Menotropins</subject><subject>Ovarian Follicle - physiology</subject><subject>ovarian function</subject><subject>Ovary - physiology</subject><subject>Ovulation Induction</subject><subject>Polycystic Ovary Syndrome</subject><subject>Recombinant Proteins</subject><subject>Reproductive Techniques, Assisted</subject><issn>1355-4786</issn><issn>1460-2369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpdkctvEzEQxlcIREvLlSOyOPS2qb32-sENWkqQIuDQIsTF8tqzjctmHfyI2v--rhKBxGlev_k0mq9p3hC8IFjR83XZlK07lwu-6Bl91hwTxnHbUa6e15z2fcuE5EfNq5TuMCacSPGyOSIdU5J17LhZX68BlQQojGi1RMZmv_P5AeWAXPQ7QGOYJm_LFG5hhuTTewT32ylEP9-iMtu1iRkcyhCjz7ULCfkZhV2ZTPZhroUr9ik7bV6MZkrw-hBPmpurT9cXy3b17fOXiw-r1jLe5ZYM42AUYYOz0jpVz6Rc9EqMRGHlMFVUWekkY5gyxySV1sKgBDgzOAXG0pPmbK-7jeFPgZT1xicL02RmCCVp0QlFsewq-O4_8C6UONfbdEdIJxmVvEKLPWRjSCnCqLfRb0x80ATrJwP03gAtNdfVgLrw9qBahg24f_jh4xVo94BPGe7_zk38rbmgotfLn7-0-Prxx3e-utSMPgJm65PY</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>Filicori, Marco</creator><creator>Cognigni, Graciela E.</creator><creator>Samara, Arafat</creator><creator>Melappioni, Silvia</creator><creator>Perri, Tiziana</creator><creator>Cantelli, Barbara</creator><creator>Parmegiani, Lodovico</creator><creator>Pelusi, Giuseppe</creator><creator>DeAloysio, Domenico</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200211</creationdate><title>The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction</title><author>Filicori, Marco ; Cognigni, Graciela E. ; Samara, Arafat ; Melappioni, Silvia ; Perri, Tiziana ; Cantelli, Barbara ; Parmegiani, Lodovico ; Pelusi, Giuseppe ; DeAloysio, Domenico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-1bfba914bdc8cd9498367597f1909d03939c8d844034d4838cceb97edabd9eac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>Female</topic><topic>folliculogenesis</topic><topic>Humans</topic><topic>Hypogonadism</topic><topic>LH activity</topic><topic>luteinizing hormone</topic><topic>Luteinizing Hormone - administration & dosage</topic><topic>Luteinizing Hormone - physiology</topic><topic>Menotropins</topic><topic>Ovarian Follicle - physiology</topic><topic>ovarian function</topic><topic>Ovary - physiology</topic><topic>Ovulation Induction</topic><topic>Polycystic Ovary Syndrome</topic><topic>Recombinant Proteins</topic><topic>Reproductive Techniques, Assisted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filicori, Marco</creatorcontrib><creatorcontrib>Cognigni, Graciela E.</creatorcontrib><creatorcontrib>Samara, Arafat</creatorcontrib><creatorcontrib>Melappioni, Silvia</creatorcontrib><creatorcontrib>Perri, Tiziana</creatorcontrib><creatorcontrib>Cantelli, Barbara</creatorcontrib><creatorcontrib>Parmegiani, Lodovico</creatorcontrib><creatorcontrib>Pelusi, Giuseppe</creatorcontrib><creatorcontrib>DeAloysio, Domenico</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction update</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filicori, Marco</au><au>Cognigni, Graciela E.</au><au>Samara, Arafat</au><au>Melappioni, Silvia</au><au>Perri, Tiziana</au><au>Cantelli, Barbara</au><au>Parmegiani, Lodovico</au><au>Pelusi, Giuseppe</au><au>DeAloysio, Domenico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction</atitle><jtitle>Human reproduction update</jtitle><addtitle>Hum. Reprod. Update</addtitle><date>2002-11</date><risdate>2002</risdate><volume>8</volume><issue>6</issue><spage>543</spage><epage>557</epage><pages>543-557</pages><issn>1355-4786</issn><eissn>1460-2369</eissn><coden>HRUPF8</coden><abstract>LH plays critical roles in the control of folliculogenesis and ovarian function in humans. LH activity administration during gonadotrophin ovulation induction can enhance ovarian response and optimise treatment. More specifically, LH activity (both LH and low-dose hCG) can support the growth and stimulate the maturation of larger ovarian follicles as a result of specific granulosa cell receptors that develop after a few days of FSH priming. This action of LH is independent of FSH, and it has been shown recently that the last stages of follicular development can be supported by sole administration of LH activity in the form of low-dose hCG, without causing premature luteinization. Reproductively competent oocytes and pregnancy can be obtained with this regimen. Furthermore, LH activity is capable of reducing the development of small ovarian follicles (<10 mm) that may predispose patients to developing complications such as the ovarian hyperstimulation syndrome. Thus, better understanding of the dynamics and mechanisms that control human folliculogenesis and a more rational and selective use of LH activity administration may allow a reduction in cost and increased safety, while maintaining a high efficacy of the ovulation induction regimens used in assisted reproduction.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>12498424</pmid><doi>10.1093/humupd/8.6.543</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1355-4786 |
| ispartof | Human reproduction update, 2002-11, Vol.8 (6), p.543-557 |
| issn | 1355-4786 1460-2369 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Chorionic Gonadotropin - administration & dosage Female folliculogenesis Humans Hypogonadism LH activity luteinizing hormone Luteinizing Hormone - administration & dosage Luteinizing Hormone - physiology Menotropins Ovarian Follicle - physiology ovarian function Ovary - physiology Ovulation Induction Polycystic Ovary Syndrome Recombinant Proteins Reproductive Techniques, Assisted |
| title | The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction |
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