Memory of Sequential Experience in the Hippocampus during Slow Wave Sleep

Rats repeatedly ran through a sequence of spatial receptive fields of hippocampal CA1 place cells in a fixed temporal order. A novel combinatorial decoding method reveals that these neurons repeatedly fired in precisely this order in long sequences involving four or more cells during slow wave sleep...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2002-12, Vol.36 (6), p.1183-1194
Main Authors: Lee, Albert K., Wilson, Matthew A.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Hippocampus - cytology
Hippocampus - physiology
Learning - physiology
Male
Memory - physiology
Neural Pathways - cytology
Neural Pathways - physiology
Neuropsychological Tests
Population
Probability
Pyramidal Cells - cytology
Pyramidal Cells - physiology
Rats
Rats, Long-Evans
Rodents
Signal Processing, Computer-Assisted
Signal Transduction - physiology
Sleep
Sleep - physiology
Synaptic Transmission - physiology
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Summary:Rats repeatedly ran through a sequence of spatial receptive fields of hippocampal CA1 place cells in a fixed temporal order. A novel combinatorial decoding method reveals that these neurons repeatedly fired in precisely this order in long sequences involving four or more cells during slow wave sleep (SWS) immediately following, but not preceding, the experience. The SWS sequences occurred intermittently in brief (∼100 ms) bursts, each compressing the behavioral sequence in time by approximately 20-fold. This rapid encoding of sequential experience is consistent with evidence that the hippocampus is crucial for spatial learning in rodents and the formation of long-term memories of events in time in humans.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(02)01096-6