Practical Synthesis of Aryl Triflates under Aqueous Conditions

A practical and efficient synthesis of aryl triflates under biphasic basic aqueous conditions is described. The current methodology provides entry into these valuable substrates that omits the use of amine bases and allows facile isolation by simple solvent evaporation after phase separation. Good y...

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Bibliographic Details
Published in:Organic letters 2002-12, Vol.4 (26), p.4717-4718
Main Authors: Frantz, Doug E, Weaver, Damian G, Carey, James P, Kress, Michael H, Dolling, Ulf H
Format: Article
Language:English
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Summary:A practical and efficient synthesis of aryl triflates under biphasic basic aqueous conditions is described. The current methodology provides entry into these valuable substrates that omits the use of amine bases and allows facile isolation by simple solvent evaporation after phase separation. Good yields can also be obtained without the use of organic solvent.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol027154z