Ginseng radix Increases Cell Proliferation in Dentate Gyrus of Rats with Streptozotocin-Induced Diabetes

In the present study, the effect of Ginseng radix on cell proliferation in the dentate gyrus of rats with streptozotocin-induced diabetes was investigated via immunohistochemistry. Aqueous extract of Ginseng radix was shown to exert no significant effect on weight in normal rats, while it prevented...

Full description

Saved in:
Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2002, Vol.25(12), pp.1550-1554
Main Authors: Lim, Baek-Vin, Shin, Min-Chul, Jang, Mi-Hyeon, Lee, Taeck-Hyun, Kim, Young-Pyo, Kim, Hyun-Bae, Lee, Kwang-Sik, Kim, Hong, Kim, Ee-Hwa, Kim, Chang-Ju
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Division - drug effects
Cell Division - physiology
cell proliferation
dentate gyrus
Dentate Gyrus - chemistry
Dentate Gyrus - cytology
Dentate Gyrus - drug effects
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - drug therapy
Dose-Response Relationship, Drug
General pharmacology
Ginseng radix
Male
Medical sciences
Panax - physiology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots - physiology
Rats
Rats, Sprague-Dawley
streptozotocin-induced diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present study, the effect of Ginseng radix on cell proliferation in the dentate gyrus of rats with streptozotocin-induced diabetes was investigated via immunohistochemistry. Aqueous extract of Ginseng radix was shown to exert no significant effect on weight in normal rats, while it prevented weight loss in rats with streptozotocin-induced diabetes. Cell proliferation in the dentate gyrus of diabetic rats was increased by Ginseng radix treatment, but it had no effect on cell proliferation in normal rats. These results suggest that Ginseng radix may help in improve the central nervous system complications of diabetes mellitus.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.25.1550