Mechanisms of enveloped RNA virus budding

To spread infection, enveloped viruses must bud from infected host cells. Recent research indicates that HIV and other enveloped RNA viruses bud by appropriating the cellular machinery that is normally used to create vesicles that bud into late endosomal compartments called multivesicular bodies. Th...

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Bibliographic Details
Published in:Trends in cell biology 2002-12, Vol.12 (12), p.569-579
Main Authors: Pornillos, Owen, Garrus, Jennifer E, Sundquist, Wesley I
Format: Article
Language:English
Subjects:
Cell Membrane - virology
Cytoplasmic Vesicles - virology
HIV - growth & development
Humans
Molecular Mimicry
Protein Transport
RNA Viruses - growth & development
Virus Assembly
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Summary:To spread infection, enveloped viruses must bud from infected host cells. Recent research indicates that HIV and other enveloped RNA viruses bud by appropriating the cellular machinery that is normally used to create vesicles that bud into late endosomal compartments called multivesicular bodies. This new model of virus budding has many potential implications for cell biology and viral pathogenesis.
ISSN:0962-8924
DOI:10.1016/S0962-8924(02)02402-9