PREDICTORS OF RESPONSE TO RADIOIODINE THERAPY IN HYPERTHYROID CATS

The objective of this retrospective study was to evaluate hyperthyroid cats for pretreatment factors that would predict response to radioiodine therapy. Hyperthyroidism was diagnosed in 193 cats based on elevated serum thyroxine levels and/or elevated thyroid to salivary gland ratios on thyroid scin...

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Bibliographic Details
Published in:Veterinary radiology & ultrasound 2002-11, Vol.43 (6), p.587-591
Main Authors: Chun, Ruthanne, Garrett, Laura D., Sargeant, Jan, Sherman, Aprill, Hoskinson, James J.
Format: Article
Language:English
Subjects:
Animals
Antithyroid Agents - administration & dosage
Antithyroid Agents - therapeutic use
Cat Diseases - diagnostic imaging
Cat Diseases - radiotherapy
Cats
Drug Administration Schedule
Hyperthyroidism - radiotherapy
Hyperthyroidism - veterinary
hyperthyroidism scintigraphy
Iodine Radioisotopes - administration & dosage
Iodine Radioisotopes - therapeutic use
methimazole
Methimazole - administration & dosage
Methimazole - therapeutic use
Predictive Value of Tests
Premedication
radioactive iodine
Radionuclide Imaging - veterinary
Records as Topic - veterinary
Regression Analysis
Retrospective Studies
Thyroxine - blood
Treatment Outcome
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Summary:The objective of this retrospective study was to evaluate hyperthyroid cats for pretreatment factors that would predict response to radioiodine therapy. Hyperthyroidism was diagnosed in 193 cats based on elevated serum thyroxine levels and/or elevated thyroid to salivary gland ratios on thyroid scintigraphy. All cats were treated with an intravenous bolus of 4 mCi of radioiodine and follow‐up serum thyroxine levels were evaluated at 1 week and 1, 3, 6, and 12 months post‐therapy. There was a significant relationship between pretreatment thyroxine values and post‐treatment thyroxine values at all of the follow‐up time points (p < 0.001). There was also a relationship between thyroid to salivary gland technetium scan ratio results and serum thyroxine values at pretreatment and at 1 week post‐treatment (p = 0.02, 0.005, respectively). A greater scan ratio was associated with higher thyroxine levels at these time points, but not at 1,3, 6 or 12 months post‐therapy. Ninety‐eight cats pretreated with methimazole were analyzed for the effect of this drug on response to therapy. Methimazole was discontinued ≥5 days before radioiodine therapy in 58 cats and
ISSN:1058-8183
1740-8261
DOI:10.1111/j.1740-8261.2002.tb01054.x