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PREDICTORS OF RESPONSE TO RADIOIODINE THERAPY IN HYPERTHYROID CATS
The objective of this retrospective study was to evaluate hyperthyroid cats for pretreatment factors that would predict response to radioiodine therapy. Hyperthyroidism was diagnosed in 193 cats based on elevated serum thyroxine levels and/or elevated thyroid to salivary gland ratios on thyroid scin...
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| Published in: | Veterinary radiology & ultrasound 2002-11, Vol.43 (6), p.587-591 |
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| cites | cdi_FETCH-LOGICAL-c4087-37befe812723f9c556b5172f5fdae5b338789de085baeeddb2d9602606090dc03 |
| container_end_page | 591 |
| container_issue | 6 |
| container_start_page | 587 |
| container_title | Veterinary radiology & ultrasound |
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| creator | Chun, Ruthanne Garrett, Laura D. Sargeant, Jan Sherman, Aprill Hoskinson, James J. |
| description | The objective of this retrospective study was to evaluate hyperthyroid cats for pretreatment factors that would predict response to radioiodine therapy. Hyperthyroidism was diagnosed in 193 cats based on elevated serum thyroxine levels and/or elevated thyroid to salivary gland ratios on thyroid scintigraphy. All cats were treated with an intravenous bolus of 4 mCi of radioiodine and follow‐up serum thyroxine levels were evaluated at 1 week and 1, 3, 6, and 12 months post‐therapy. There was a significant relationship between pretreatment thyroxine values and post‐treatment thyroxine values at all of the follow‐up time points (p < 0.001). There was also a relationship between thyroid to salivary gland technetium scan ratio results and serum thyroxine values at pretreatment and at 1 week post‐treatment (p = 0.02, 0.005, respectively). A greater scan ratio was associated with higher thyroxine levels at these time points, but not at 1,3, 6 or 12 months post‐therapy. Ninety‐eight cats pretreated with methimazole were analyzed for the effect of this drug on response to therapy. Methimazole was discontinued ≥5 days before radioiodine therapy in 58 cats and |
| doi_str_mv | 10.1111/j.1740-8261.2002.tb01054.x |
| format | article |
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Hyperthyroidism was diagnosed in 193 cats based on elevated serum thyroxine levels and/or elevated thyroid to salivary gland ratios on thyroid scintigraphy. All cats were treated with an intravenous bolus of 4 mCi of radioiodine and follow‐up serum thyroxine levels were evaluated at 1 week and 1, 3, 6, and 12 months post‐therapy. There was a significant relationship between pretreatment thyroxine values and post‐treatment thyroxine values at all of the follow‐up time points (p < 0.001). There was also a relationship between thyroid to salivary gland technetium scan ratio results and serum thyroxine values at pretreatment and at 1 week post‐treatment (p = 0.02, 0.005, respectively). A greater scan ratio was associated with higher thyroxine levels at these time points, but not at 1,3, 6 or 12 months post‐therapy. Ninety‐eight cats pretreated with methimazole were analyzed for the effect of this drug on response to therapy. Methimazole was discontinued ≥5 days before radioiodine therapy in 58 cats and <5 days in 31 cats, in 9 cats the number of days off methimazole was unknown. There was no difference in response to radioiodine based upon when methimazole was discontinued (p = 0.70).</description><identifier>ISSN: 1058-8183</identifier><identifier>EISSN: 1740-8261</identifier><identifier>DOI: 10.1111/j.1740-8261.2002.tb01054.x</identifier><identifier>PMID: 12502116</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Antithyroid Agents - administration & dosage ; Antithyroid Agents - therapeutic use ; Cat Diseases - diagnostic imaging ; Cat Diseases - radiotherapy ; Cats ; Drug Administration Schedule ; Hyperthyroidism - radiotherapy ; Hyperthyroidism - veterinary ; hyperthyroidism scintigraphy ; Iodine Radioisotopes - administration & dosage ; Iodine Radioisotopes - therapeutic use ; methimazole ; Methimazole - administration & dosage ; Methimazole - therapeutic use ; Predictive Value of Tests ; Premedication ; radioactive iodine ; Radionuclide Imaging - veterinary ; Records as Topic - veterinary ; Regression Analysis ; Retrospective Studies ; Thyroxine - blood ; Treatment Outcome</subject><ispartof>Veterinary radiology & ultrasound, 2002-11, Vol.43 (6), p.587-591</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4087-37befe812723f9c556b5172f5fdae5b338789de085baeeddb2d9602606090dc03</citedby><cites>FETCH-LOGICAL-c4087-37befe812723f9c556b5172f5fdae5b338789de085baeeddb2d9602606090dc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12502116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chun, Ruthanne</creatorcontrib><creatorcontrib>Garrett, Laura D.</creatorcontrib><creatorcontrib>Sargeant, Jan</creatorcontrib><creatorcontrib>Sherman, Aprill</creatorcontrib><creatorcontrib>Hoskinson, James J.</creatorcontrib><title>PREDICTORS OF RESPONSE TO RADIOIODINE THERAPY IN HYPERTHYROID CATS</title><title>Veterinary radiology & ultrasound</title><addtitle>Vet Radiol Ultrasound</addtitle><description>The objective of this retrospective study was to evaluate hyperthyroid cats for pretreatment factors that would predict response to radioiodine therapy. Hyperthyroidism was diagnosed in 193 cats based on elevated serum thyroxine levels and/or elevated thyroid to salivary gland ratios on thyroid scintigraphy. All cats were treated with an intravenous bolus of 4 mCi of radioiodine and follow‐up serum thyroxine levels were evaluated at 1 week and 1, 3, 6, and 12 months post‐therapy. There was a significant relationship between pretreatment thyroxine values and post‐treatment thyroxine values at all of the follow‐up time points (p < 0.001). There was also a relationship between thyroid to salivary gland technetium scan ratio results and serum thyroxine values at pretreatment and at 1 week post‐treatment (p = 0.02, 0.005, respectively). A greater scan ratio was associated with higher thyroxine levels at these time points, but not at 1,3, 6 or 12 months post‐therapy. Ninety‐eight cats pretreated with methimazole were analyzed for the effect of this drug on response to therapy. Methimazole was discontinued ≥5 days before radioiodine therapy in 58 cats and <5 days in 31 cats, in 9 cats the number of days off methimazole was unknown. There was no difference in response to radioiodine based upon when methimazole was discontinued (p = 0.70).</description><subject>Animals</subject><subject>Antithyroid Agents - administration & dosage</subject><subject>Antithyroid Agents - therapeutic use</subject><subject>Cat Diseases - diagnostic imaging</subject><subject>Cat Diseases - radiotherapy</subject><subject>Cats</subject><subject>Drug Administration Schedule</subject><subject>Hyperthyroidism - radiotherapy</subject><subject>Hyperthyroidism - veterinary</subject><subject>hyperthyroidism scintigraphy</subject><subject>Iodine Radioisotopes - administration & dosage</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>methimazole</subject><subject>Methimazole - administration & dosage</subject><subject>Methimazole - therapeutic use</subject><subject>Predictive Value of Tests</subject><subject>Premedication</subject><subject>radioactive iodine</subject><subject>Radionuclide Imaging - veterinary</subject><subject>Records as Topic - veterinary</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Thyroxine - blood</subject><subject>Treatment Outcome</subject><issn>1058-8183</issn><issn>1740-8261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqVkF1PwjAUhhujEUX_glm88G7ztKVr54UJbAOWEEbGwHDV7KNLQBBcIcK_twSC1_bmtDnPeU_6IPSMwcHmvC4czFtgC-JihwAQZ5sDBtZy9lfo7tK6NndgwhZY0Aa613phUMYJv0UNTBgQjN071BklYRD5aZyMrbhrJeF4FA_HoZXGVtIOojiKg2honv0waY9mVjS0-rNRmKT9WRJHgeW30_EDuqmypVaP59pEk26Y-n17EPcivz2wixYIblOeq0oJTDihlVcw5uYMc1KxqswUyykVXHilAsHyTKmyzEnpuUBccMGDsgDaRC-n3E29_t4pvZWruS7Ucpl9qfVOS_M1j7ukZcC3E1jUa61rVclNPV9l9UFikEeDciGPmuRRkzwalGeDcm-Gn85bdvlKlX-jZ2UGeD8BP_OlOvwjWk6TCRPcBNingLneqv0lIKs_pcspZ_Jj2JNBbzrFpAOS0l_Wjojh</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>Chun, Ruthanne</creator><creator>Garrett, Laura D.</creator><creator>Sargeant, Jan</creator><creator>Sherman, Aprill</creator><creator>Hoskinson, James J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200211</creationdate><title>PREDICTORS OF RESPONSE TO RADIOIODINE THERAPY IN HYPERTHYROID CATS</title><author>Chun, Ruthanne ; Garrett, Laura D. ; Sargeant, Jan ; Sherman, Aprill ; Hoskinson, James J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4087-37befe812723f9c556b5172f5fdae5b338789de085baeeddb2d9602606090dc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antithyroid Agents - administration & dosage</topic><topic>Antithyroid Agents - therapeutic use</topic><topic>Cat Diseases - diagnostic imaging</topic><topic>Cat Diseases - radiotherapy</topic><topic>Cats</topic><topic>Drug Administration Schedule</topic><topic>Hyperthyroidism - radiotherapy</topic><topic>Hyperthyroidism - veterinary</topic><topic>hyperthyroidism scintigraphy</topic><topic>Iodine Radioisotopes - administration & dosage</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>methimazole</topic><topic>Methimazole - administration & dosage</topic><topic>Methimazole - therapeutic use</topic><topic>Predictive Value of Tests</topic><topic>Premedication</topic><topic>radioactive iodine</topic><topic>Radionuclide Imaging - veterinary</topic><topic>Records as Topic - veterinary</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Thyroxine - blood</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chun, Ruthanne</creatorcontrib><creatorcontrib>Garrett, Laura D.</creatorcontrib><creatorcontrib>Sargeant, Jan</creatorcontrib><creatorcontrib>Sherman, Aprill</creatorcontrib><creatorcontrib>Hoskinson, James J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary radiology & ultrasound</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chun, Ruthanne</au><au>Garrett, Laura D.</au><au>Sargeant, Jan</au><au>Sherman, Aprill</au><au>Hoskinson, James J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PREDICTORS OF RESPONSE TO RADIOIODINE THERAPY IN HYPERTHYROID CATS</atitle><jtitle>Veterinary radiology & ultrasound</jtitle><addtitle>Vet Radiol Ultrasound</addtitle><date>2002-11</date><risdate>2002</risdate><volume>43</volume><issue>6</issue><spage>587</spage><epage>591</epage><pages>587-591</pages><issn>1058-8183</issn><eissn>1740-8261</eissn><abstract>The objective of this retrospective study was to evaluate hyperthyroid cats for pretreatment factors that would predict response to radioiodine therapy. Hyperthyroidism was diagnosed in 193 cats based on elevated serum thyroxine levels and/or elevated thyroid to salivary gland ratios on thyroid scintigraphy. All cats were treated with an intravenous bolus of 4 mCi of radioiodine and follow‐up serum thyroxine levels were evaluated at 1 week and 1, 3, 6, and 12 months post‐therapy. There was a significant relationship between pretreatment thyroxine values and post‐treatment thyroxine values at all of the follow‐up time points (p < 0.001). There was also a relationship between thyroid to salivary gland technetium scan ratio results and serum thyroxine values at pretreatment and at 1 week post‐treatment (p = 0.02, 0.005, respectively). A greater scan ratio was associated with higher thyroxine levels at these time points, but not at 1,3, 6 or 12 months post‐therapy. Ninety‐eight cats pretreated with methimazole were analyzed for the effect of this drug on response to therapy. Methimazole was discontinued ≥5 days before radioiodine therapy in 58 cats and <5 days in 31 cats, in 9 cats the number of days off methimazole was unknown. There was no difference in response to radioiodine based upon when methimazole was discontinued (p = 0.70).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12502116</pmid><doi>10.1111/j.1740-8261.2002.tb01054.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Antithyroid Agents - administration & dosage Antithyroid Agents - therapeutic use Cat Diseases - diagnostic imaging Cat Diseases - radiotherapy Cats Drug Administration Schedule Hyperthyroidism - radiotherapy Hyperthyroidism - veterinary hyperthyroidism scintigraphy Iodine Radioisotopes - administration & dosage Iodine Radioisotopes - therapeutic use methimazole Methimazole - administration & dosage Methimazole - therapeutic use Predictive Value of Tests Premedication radioactive iodine Radionuclide Imaging - veterinary Records as Topic - veterinary Regression Analysis Retrospective Studies Thyroxine - blood Treatment Outcome |
| title | PREDICTORS OF RESPONSE TO RADIOIODINE THERAPY IN HYPERTHYROID CATS |
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