Evaluation of the immune response following exposure of mice to bisphenol A: Induction of th1 cytokine and prolactin by BPA exposure in the mouse spleen cells

• Published in: Archives of pharmacal research 2002-12, Vol.25 (6), p.946-953
• Main Authors: Youn, Ji -Youn, Park, Hyo -Young, Lee, Jung -Won, Jung, In -Ok, Choi, Keum -Hwa, Kim, Kyungjae, Cho, Kyung -Hea
• Format: Article
• Language: English
• Subjects: Animals; Benzhydryl Compounds; bisphenol A; body weight; cell-mediated immunity; concanavalin A; Cytokines - biosynthesis; drinking water; Drug Evaluation, Preclinical - methods; endocrine-disrupting chemicals; estrogenic properties; GATA transcription factors; immune response; Immunity, Cellular - drug effects; interferon regulatory factor-1; interferon-gamma; interleukin-4; Male; Mice; Mice, Inbred ICR; Phenols - pharmacology; prolactin; Prolactin - biosynthesis; Prolactin - secretion; propane; reverse transcriptase polymerase chain reaction; RNA, Messenger - biosynthesis; spleen; Spleen - cytology; Spleen - drug effects; Spleen - immunology; Spleen - metabolism; splenocytes; Th1 Cells - drug effects; Th1 Cells - immunology; Th1 Cells - metabolism
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/bf02977018

Bisphenol A [2, 2 bis (4-hydoxyphenyl) propane; BPA] is a widely used endocrine disruptors and has estrogenic activities. Although interests on biological effect of BPA are rising, evidences of its effect on immune system are lacking. We investigated that the effect of BPA on immune parameters to postulate the mechanism, and BPA interruptions between neuroendocrine and immune system. BPA was administrated to mice by p.o. (as a drinking water) dose on 0.015, 1.5 and 30 mg/ml for 4 weeks. The BPA treatment did not result in any change in body weight, spleen weight and distribution of lymphocyte subpopulation collected from spleen. BPA induced prolactin production in spleen, and exposure of BPA increased the activity of splenocyte proliferation in response to Con A (p