Purealidin S and Purpuramine J, Bromotyrosine Alkaloids from the Fijian Marine Sponge Druinella sp

Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moder...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-12, Vol.65 (12), p.1798-1801
Main Authors: Tabudravu, Jioji N, Jaspars, Marcel
Format: Article
Language:English
Subjects:
Alkaloids
Animals
Antineoplastic Agents
Aplysinellidae
Biological and medical sciences
Bromobenzenes - chemistry
Bromobenzenes - isolation & purification
Bromobenzenes - pharmacology
bromotyrosine alkaloids
Drug Screening Assays, Antitumor
Druinella
Female
Fiji
General pharmacology
Humans
Leukemia
Marine
Medical sciences
Molecular Structure
natural products
Ovarian Neoplasms
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera
Purealidin S
purpuramine J
Tumor Cells, Cultured - drug effects
Tyrosine - analogs & derivatives
Tyrosine - chemistry
Tyrosine - isolation & purification
Tyrosine - pharmacology
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Summary:Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.
ISSN:0163-3864
1520-6025
DOI:10.1021/np020275n