Alveolar neutrophilia is a predictor for the bronchiolitis obliterans syndrome, and increases with degree of severity

Background: Bronchiolitis obliterans syndrome (BOS) is a common complication of lung transplantation (LT), associated with a tremendous mortality and morbidity. Recent innovative research has focused on bronchoalveolar lavage (BAL) analysis, assuming that neutrophilia might be a marker of chronic re...

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Published in:Transplant immunology 2002-11, Vol.10 (4), p.303-310
Main Authors: Devouassoux, Gilles, Drouet, Christian, Pin, Isabelle, Brambilla, Christian, Brambilla, Elisabeth, Colle, Pierre-Emmanuel, Pison, Christophe
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bronchiolitis Obliterans - diagnosis
Bronchiolitis Obliterans - pathology
Bronchiolitis obliterans syndrome
Bronchoalveolar lavage
Bronchoalveolar Lavage Fluid - cytology
Cell Count
Graft Rejection - pathology
Humans
Lung transplantation
Lung Transplantation - adverse effects
Middle Aged
Neutrophil
Neutrophils - physiology
Pulmonary Alveoli - pathology
Retrospective Studies
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Summary:Background: Bronchiolitis obliterans syndrome (BOS) is a common complication of lung transplantation (LT), associated with a tremendous mortality and morbidity. Recent innovative research has focused on bronchoalveolar lavage (BAL) analysis, assuming that neutrophilia might be a marker of chronic rejection. Patients and methods: To address this issue, we retrospectively analyzed 258 sequential BAL from 44 lung transplant recipients, having survived for more than 3 months after surgery. Results: At the end of the follow-up, 22, 7, 7 and 8 patients had BOS stage 0, 1, 2 and 3, respectively. The total cell count and neutrophilia increased with BOS severity (P
ISSN:0966-3274
1878-5492
DOI:10.1016/S0966-3274(02)00074-6