FC gamma RIIa polymorphism in patients with rheumatoid arthritis

Polymorphism of phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complex contain IgG2. Fc gamma RIIa genotyping in 82 patients with rheumatoid arthritis (RA) and 148 healthy subjects was performed using the polymerase chain reaction tec...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2002-11, Vol.20 (6), p.841-844
Main Authors: Pawlik, A, Ostanek, L, Brzosko, I, Brzosko, M, Fabrycy, I Fiedorowicz, Florczak, M, Szklarz, B Gawronska
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antigens, CD - genetics
Arthritis, Rheumatoid - epidemiology
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - physiopathology
DNA - analysis
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Poland - epidemiology
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, IgG - genetics
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Summary:Polymorphism of phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complex contain IgG2. Fc gamma RIIa genotyping in 82 patients with rheumatoid arthritis (RA) and 148 healthy subjects was performed using the polymerase chain reaction technique with allele specific primers. No significant relation between Fc gamma RIIa genotypes and susceptibility to RA was observed, but extraarticular complications with high frequency were revealed in patients with R/R131 genotype. The results suggest that the Fc gamma RIIa polymorphism is not a risk factor for RA.
ISSN:0392-856X