Cardioprotective effect of energostim during occlusion of coronary artery

Experiments on dogs showed that energostim, a directly acting antihypoxant, injected 15 min after occlusion of the upper one-third of the left descending branch of the interventricular coronary artery produced a pronounced cardioprotective effect. The effect was confirmed by electron microscopy (eva...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-09, Vol.134 (3), p.291-298
Main Authors: Karsanov, N V, Sukoyan, G V, Chikobava, E A, Karsanov, Z N, Yarovaya, E V, Tatulashvili, D R, Gorelishvili, I I
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Coronary Disease - prevention & control
Coronary Disease - therapy
Coronary Vessels - pathology
Dogs
Heart Ventricles - ultrastructure
Hemodynamics
Microscopy, Electron
Myocardial Infarction - prevention & control
Myocardial Infarction - therapy
Myocardial Ischemia - drug therapy
Myocardium - ultrastructure
Necrosis
Phosphocreatine - metabolism
Time Factors
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Summary:Experiments on dogs showed that energostim, a directly acting antihypoxant, injected 15 min after occlusion of the upper one-third of the left descending branch of the interventricular coronary artery produced a pronounced cardioprotective effect. The effect was confirmed by electron microscopy (evaluation the necrotic focus), biochemical tests of the heart and blood, and changes in intracardiac hemodynamics (recovery of systolic and diastolic functions). The cardioprotective effect of energostim greatly surpasses that of routine therapy applied during acute myocardium infarction.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1021576006103