Effect of Maksar on antioxidant system in rats with type IIa alimentary hyperlipoproteinemia

The development of type IIa alimentary hyperlipoproteinemia in rats was accompanied by changes in activity of glutathione-dependent enzymes, exhaustion of the reserves of antioxidant vitamins in the liver and blood, and intensification of lipid peroxidation. The hepatoprotective preparation Maksar o...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-09, Vol.134 (3), p.230-232
Main Authors: Yan'kova, V I, Gvozdenko, T A, Ivanova, I L, Fedoreev, S A, Kulesh, N I
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Disease Models, Animal
Flavonoids
Glutathione - metabolism
Hyperlipoproteinemia Type II - metabolism
Hyperlipoproteinemia Type II - therapy
Lipid Peroxidation
Lipids - blood
Liver - metabolism
Male
Phenols - pharmacology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Polymers - pharmacology
Polyphenols
Rats
Rats, Wistar
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Summary:The development of type IIa alimentary hyperlipoproteinemia in rats was accompanied by changes in activity of glutathione-dependent enzymes, exhaustion of the reserves of antioxidant vitamins in the liver and blood, and intensification of lipid peroxidation. The hepatoprotective preparation Maksar obtained from far-eastern plants Maachia amurensis and containing natural biological antioxidants normalized blood lipid composition, corrected liver lipidosis, and improved the antioxidant defense system.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1021439030694