Gastric Irradiation for Low-grade MALT Lymphoma of the Stomach: Report of Two Cases and Review of the Literature

We report the case history of two patients treated with primary gastric irradiation for localized low-grade mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach that failed to respond to anti- Helicobacter pylori antibiotics. One patient refused gastrectomy and the other was considered u...

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Bibliographic Details
Published in:Clinical oncology (Royal College of Radiologists (Great Britain)) 2002-12, Vol.14 (6), p.464-467
Main Authors: El-Modir, A., Glaholm, J.
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Disease-Free Survival
Gastrectomy
Helicobacter Infections - complications
Helicobacter pylori - pathogenicity
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, B-Cell, Marginal Zone - pathology
Lymphoma, B-Cell, Marginal Zone - radiotherapy
Male
MALT, gastrectomy, gastric lymphoma, radiotherapy
Medical sciences
Middle Aged
Radiation therapy and radiosensitizing agent
Stomach Neoplasms - pathology
Stomach Neoplasms - radiotherapy
Treatment Outcome
Treatment with physical agents
Treatment. General aspects
Tumors
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Summary:We report the case history of two patients treated with primary gastric irradiation for localized low-grade mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach that failed to respond to anti- Helicobacter pylori antibiotics. One patient refused gastrectomy and the other was considered unfit for surgery. Both patients obtained a biopsy–confirmed complete response and are well and disease free after a median follow-up time of 28 months. A review of the literature on the treatment options for this condition has been undertaken. Gastric irradiation is an effective and safe alternative to gastrectomy in the treatment of low-grade MALT lymphoma of the stomach with the added advantage of organ preservation. Copyright 2002 The Royal College of Radiologists. Published by Elsevier Science Ltd. All rights reserved.
ISSN:0936-6555
1433-2981
DOI:10.1053/clon.2001.0009