Disseminated Mycobacterium avium Complex Infection: Clinical Identification and Epidemiologic Trends

To evaluate the incidence of disseminated Mycobacterium avium complex infection (DMAC) and to define the association between signs and symptoms and development of DMAC in patients with human immunodeficiency virus (HIV) infection, all cases ofDMAC at Grady Memorial Hospital Infectious Disease Clinic...

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Bibliographic Details
Published in:The Journal of infectious diseases 1992-03, Vol.165 (3), p.577-580
Main Authors: Havlik, Joseph A., Horsburgh, C. Robert, Metchock, Beverly, Williams, Portia P., Fann, S. Alan, Thompson, Sumner E.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
Adolescent
Adult
Age Factors
Aged
AIDS
AIDS/HIV
Anemia
Biological and medical sciences
Blood
CD4-Positive T-Lymphocytes
Child
Concise Communications
Epidemiology
Female
Fever
Georgia - epidemiology
HIV
HIV Infections - complications
Humans
Incidence
Infections
Infectious diseases
Leukocyte Count
Male
Medical sciences
Middle Aged
Mycobacterium avium complex
Mycobacterium avium-intracellulare Infection - complications
Mycobacterium avium-intracellulare Infection - diagnosis
Mycobacterium avium-intracellulare Infection - epidemiology
Prospective Studies
Retrospective Studies
Symptoms
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Summary:To evaluate the incidence of disseminated Mycobacterium avium complex infection (DMAC) and to define the association between signs and symptoms and development of DMAC in patients with human immunodeficiency virus (HIV) infection, all cases ofDMAC at Grady Memorial Hospital Infectious Disease Clinic (Atlanta) between 1985 and 1990 were reviewed, and a prospective study of the association of symptoms with DMAC was done. Between 1985 and 1990, DMAC occurred in 16% of patients with AIDS. Incidence increased from 5.7% in 19851988 to 23.3% in 1989–1990 (P < .001). Median time from AIDS diagnosis to diagnosis of DMAC increased from 4.5 months in 1985–1988 to 8 months in 1989–1990 (P < .02). In the prospective study, DMAC was seen only in persons with a CD4+ count
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/165.3.577