Reactions of hemopoietic granulocytic stem in hypoxia of different severity

We studied the reactions of granulocytic hemopoietic stem after acute hypoxia and during the development of posthypoxic encephalopathy. Damage to brain structures was associated with intensification of the bone marrow hemopoiesis due to activation of hemopoiesis-inducing microenvironment and more in...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-10, Vol.134 (4), p.325-328
Main Authors: Zyuz'kov, G N, Gur'yantseva, L A, Suslov, N I, Dygai, A M, Gol'dberg, E D
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - pathology
Colony-Forming Units Assay
Granulocytes - pathology
Hematopoietic Stem Cells - pathology
Hypoxia - pathology
Hypoxia, Brain - pathology
Kinetics
Male
Mice
Mice, Inbred CBA
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Summary:We studied the reactions of granulocytic hemopoietic stem after acute hypoxia and during the development of posthypoxic encephalopathy. Damage to brain structures was associated with intensification of the bone marrow hemopoiesis due to activation of hemopoiesis-inducing microenvironment and more intense formation of hemopoietic islets, despite reduced proliferative capacity of granulocytic precursors.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1021935609855