Patterns of Cerebral Blood Flow in Schizophrenia

Positron emission tomography was used to study the relationship between rCBF and symptom profiles in 30 schizophrenic patients. Factor analysis confirmed that the symptoms segregated into three syndromes – psychomotor poverty, disorganisation, and reality distortion – described previously. Analysis...

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Bibliographic Details
Published in:British journal of psychiatry 1992-02, Vol.160 (2), p.179-186
Main Authors: Liddle, P. F., Friston, K. J., Frith, C. D., Hirsch, S. R., Jones, T., Frackowiak, R. S. J.
Format: Article
Language:English
Subjects:
Adult
Blood flow
Brain
Brain - physiopathology
Cerebral blood flow
Cerebrovascular Circulation
Cortex
Cortex (frontal)
Cortex (temporal)
Distortion
Emissions
Factor analysis
Female
Humans
Male
Medial temporal lobe
Mental disorders
Neural networks
Perfusion
Positron emission tomography
Poverty
Psychiatric Status Rating Scales
Schizophrenia
Schizophrenia - classification
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Temporal lobe
Temporal Lobe - blood supply
Tomography
Tomography, Emission-Computed
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Summary:Positron emission tomography was used to study the relationship between rCBF and symptom profiles in 30 schizophrenic patients. Factor analysis confirmed that the symptoms segregated into three syndromes – psychomotor poverty, disorganisation, and reality distortion – described previously. Analysis of the correlations between syndrome scores and rCBF revealed that each syndrome was associated with a specific pattern of perfusion in paralimbic and association cortex, and in related subcortical nuclei. The study confirmed predictions that psychomotor poverty and disorganisation are associated with altered perfusion at different loci in the pre-frontal cortex, and reality distortion with altered perfusion in the medial temporal lobe. The perfusion patterns suggest that the abnormalities of brain function underlying each of the three syndromes are not confined to single loci, but involve distributed neuronal networks.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.160.2.179