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The Bench Press Mark
Abnormal muscle uptake in multiple sites following strenuous exercise has been extensively reported. Muscle localization of bone agents has also been described in conditions associated with muscle damage such as myositis ossificans, polymyositis, rhabdomyolysis, and trauma. Muscle damage from strenu...
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Published in: | Clinical nuclear medicine 1992-01, Vol.17 (1), p.56-57 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Abnormal muscle uptake in multiple sites following strenuous exercise has been extensively reported. Muscle localization of bone agents has also been described in conditions associated with muscle damage such as myositis ossificans, polymyositis, rhabdomyolysis, and trauma. Muscle damage from strenuous exercise causes disruption of muscle cells with an influx of calcium into the damaged cell. The bone-seeking agent then localizes to intracellular calcium, amorphous calcium phosphate, and crystalline hydroxyapatite. Other mechanisms of uptake by damaged skeletal muscle may include hyperemia, adsorption onto soft-tissue calcium and immature collagen, and binding to tissue receptors and denatured proteins. Though many explanations have been postulated, the exact mechanism of the localization of boneseeking agents in injured skeletal muscle remains unclear. |
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ISSN: | 0363-9762 1536-0229 |
DOI: | 10.1097/00003072-199201000-00018 |