Prognostic factors in anal carcinoma

The pathologist’s role in the evaluation of patients with anal squamous carcinoma is now largely restricted to establishing the diagnosis on small biopsies. Staging is performed by imaging techniques and grading is uncertain as the biopsy may not be representative of the whole tumour. Histological s...

Full description

Saved in:
Bibliographic Details
Published in:Pathology 2002, Vol.34 (6), p.573-578
Main Author: Fenger, Claus
Format: Article
Language:English
Subjects:
Anal squamous carcinoma
Anus Neoplasms - diagnosis
Anus Neoplasms - etiology
Anus Neoplasms - metabolism
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - secondary
Cell Division
Cytogenetic Analysis
Humans
Immunohistochemistry
Prognosis
prognostic factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pathologist’s role in the evaluation of patients with anal squamous carcinoma is now largely restricted to establishing the diagnosis on small biopsies. Staging is performed by imaging techniques and grading is uncertain as the biopsy may not be representative of the whole tumour. Histological subtyping is unreliable and has not been proven to be of prognostic significance. A considerable effort resulting in nearly 50 reports on cytogenetic, flow cytometric, immunohistochemical and other investigations has given new insight into pathogenesis but little guidance with regard to the individual prognosis or choice of treatment. It is concluded that future research should concentrate on larger, probably multicentre series using standardised methods and criteria for evaluation.
ISSN:0031-3025
1465-3931
DOI:10.1080/0031302021000035956