A LONGITUDINAL STUDY OF LEPTIN AND APPETITE, RESTING ENERGY EXPENDITURE AND BODY FAT MASS IN WEIGHT-STABLE CANCER PATIENTS

Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9μg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations w...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2002-11, Vol.20 (4), p.174-177
Main Authors: Maguire, Roma, McMillan, Donald C, Wallace, A.Michael, McArdle, Colin
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - secondary
Adipose Tissue - pathology
Adult
Aged
Appetite
Body Composition
Body Weight
C-Reactive Protein - analysis
colorectal liver metastases/leptin/appetite/energy metabolism/body fat mass
Colorectal Neoplasms - metabolism
Energy Metabolism
Humans
Hydrocortisone - blood
Insulin - blood
Leptin - blood
Liver Neoplasms - metabolism
Liver Neoplasms - secondary
Longitudinal Studies
Male
Middle Aged
Serum Albumin - analysis
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Summary:Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9μg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (rs=0.519, P=0.040) and with the changes after 6 weeks (rs=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.
ISSN:1043-4666
1096-0023
DOI:10.1006/cyto.2002.1995