Localization of c-Fos protein in the rat spinal cord after carrageenan treatment

We have characterized segmental and laminar distribution patterns of Fos-immunopositive (Fos-IP) neurons in spinal cord segments L3–L6 after carrageenan treatment. A large number of Fos-IP neurons was found in the medial region of the ipsilateral dorsal horn laminae I–II at 4 and 6 h postinjection (...

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Bibliographic Details
Published in:Acta histochemica 2002-01, Vol.104 (4), p.381-385
Main Authors: Jergova, Stanislava, Cizkova, Dasa, Orendacova, Judita, Cizek, Milan, Marsala, Jozef
Format: Article
Language:English
Subjects:
Animals
c-Fos protein
carrageenan
Carrageenan - pharmacology
Hindlimb - drug effects
Hindlimb - pathology
inflammation
Inflammation - chemically induced
Inflammation - metabolism
Inflammation - pathology
Male
Neurons - drug effects
Neurons - metabolism
Neurons - pathology
Proto-Oncogene Proteins c-fos - metabolism
Rats
Rats, Wistar
spinal cord
Spinal Cord - drug effects
Spinal Cord - metabolism
Spinal Cord - pathology
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Summary:We have characterized segmental and laminar distribution patterns of Fos-immunopositive (Fos-IP) neurons in spinal cord segments L3–L6 after carrageenan treatment. A large number of Fos-IP neurons was found in the medial region of the ipsilateral dorsal horn laminae I–II at 4 and 6 h postinjection (pi). At one day pi, the number of Fos-IP neurons was decreased significantly, which correlated with suppression of inflammation in the affected hind paw. Bilaterally, Fos-IP neurons reappeared in the L3–L6 spinal cord segments at 3–4 days pi, mainly in the deep laminae LV–LVI. However, signs of inflammation had distinctly attenuated. Our data indicate a biphasic trend in Fos-IP in this experimental model of inflammation.
ISSN:0065-1281
1618-0372
DOI:10.1078/0065-1281-00679