Pharmacokinetic and metabolic aspects of the moclobemide-food interaction

The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral...

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Bibliographic Details
Published in:Psychopharmacologia 1992-02, Vol.106 (S1), p.S37-S39
Main Authors: COLE, A. F. D, BAXTER, J. G, JACKSON, B. J, HEW-WING, P, GÜNTERT, T. W, LALKA, D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Benzamides - pharmacokinetics
Biological and medical sciences
Biological Availability
Diet
Dietary Proteins - pharmacology
Food
Humans
Indocyanine Green
Injections, Intravenous
Liver Circulation - drug effects
Liver Function Tests
Male
Medical sciences
Moclobemide
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
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Summary:The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral administration apparently, because the influence of blood flow changes to the liver on hepatic first-pass metabolism (AUC increases) and on systemic clearance (AUC decreases) balance each other out.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02246232