Effect of isorhapontigenin on respiratory burst of rat neutrophils

The effect of Isorhapontigenin (Iso) isolated from Belamcanda chinensis on respiratory burst of rat neutrophils was investigated. Iso (1, 10, 100 mmol/l) showed an inhibitory effect on superoxide anion and hydrogen peroxide production in phorbol myristate acetate (PMA) activated rat neutrophils in a...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2002-12, Vol.9 (8), p.734-738
Main Authors: Nan Fang, Ya, Tao Liu, Geng
Format: Article
Language:English
Subjects:
Animals
anti-oxidant
Dose-Response Relationship, Drug
Free Radical Scavengers - administration & dosage
Free Radical Scavengers - pharmacology
Free Radical Scavengers - therapeutic use
Isorhapontigenin
Male
neutrophil
Neutrophils
Neutrophils - physiology
oxygen free radicals
Physiological aspects
Phytotherapy
Rats
Rats as laboratory animals
Rats, Wistar
Respiratory Burst - drug effects
Stilbenes - administration & dosage
Stilbenes - pharmacology
Stilbenes - therapeutic use
β-glucuronidase
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Summary:The effect of Isorhapontigenin (Iso) isolated from Belamcanda chinensis on respiratory burst of rat neutrophils was investigated. Iso (1, 10, 100 mmol/l) showed an inhibitory effect on superoxide anion and hydrogen peroxide production in phorbol myristate acetate (PMA) activated rat neutrophils in a concentration-dependent manner. Scanning electron microscopy detected that Iso (100 mmol/l) protected against surface changes in rat neutrophils stimulated with PMA. Also, 100mmol/l Iso inhibited the release of β-glucuronidase from the activated neutrophils. Electron-spin resonance (ESR) detected that Iso scavenged oxygen free radicals generated in the PMA activated Neutrophils. These results suggest that Iso inhibits respiratory burst of PMA-activated rat neutrophils by scavenging oxygen free radicals.
ISSN:0944-7113
1618-095X
DOI:10.1078/094471102321621359