Molecular action of androgens

The androgen receptor (AR), which mediates androgen action in the cell, belongs to the superfamily of nuclear receptors, a large group of transcription factors. Recent studies have described how the AR acts on specific target genes. The receptor's specificity of action depends on its regulation...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2002-12, Vol.198 (1), p.15-24
Main Authors: Gobinet, J, Poujol, N, Sultan, Ch
Format: Article
Language:English
Subjects:
Androgen receptor
Androgens - chemistry
Androgens - metabolism
Binding Sites
Chromosomes, Human, X
Cofactor
Humans
Ligands
Models, Molecular
Protein Binding
Protein Conformation
Receptors, Androgen - chemistry
Receptors, Androgen - metabolism
Structure
Transactivation regulation
Transcription factor
Transcriptional Activation
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Summary:The androgen receptor (AR), which mediates androgen action in the cell, belongs to the superfamily of nuclear receptors, a large group of transcription factors. Recent studies have described how the AR acts on specific target genes. The receptor's specificity of action depends on its regulation at different levels: expression in the cells, ligand binding and DNA-specific sequence recognition by structurally conserved domains and regulation by transcriptional factors in an integrated response. We propose, here, an overview of recent works on the molecular regulation of androgen-dependent genes by AR.
ISSN:0303-7207
1872-8057
DOI:10.1016/S0303-7207(02)00364-7